Three radioligands have been commonly used to label putative nicotinic cholinoceptors in
the mammalian central nervous system: the agonists [3H] nicotine and [3H] acetylcholine …

In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the
cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study,[3 …

Binding sites for nicotine in the central nervous system are receiving increasing attention for
two main reasons. Firstly, nicotine is a good candidate for identifying nicotinic acetylcholine …

Publisher Summary This chapter investigates the nicotinic receptors in the brain of monkey
and man by positron emission tomography. The topographic distribution and the …

In postmortem investigations of patients with dementia of Alzheimer type (AD/SDAT)(n= 14)
the brain weight was significantly reduced when compared to controls (n= 16). In four …

Abstract (S)-and (R)-[11 C] nicotine were synthesized by methylation of (S)-and (R)-
nornicotine using [11 C] methyl iodide. Following their intravenous injection in tracer doses …

Volumes 7 and 8 of the Handbook were published in 1977. In Volume 7 methods for
studying unconditioned and conditioned behavior were reviewed. Attention was given to …

The relative distribution of muscarinic and nicotinic cholinergic receptors labeled with [3 H]
acetylcholine was determined using autoradiography.[3 H] acetylcholine binding to high …

In order to investigate [11 C] nicotine binding and metabolism in the living human brain by
PET, routine protocols were developed for the preparation and purification of (S)-and (R)-[11 …

(+/-)-[3H] Nicotine binds specifically to rat brain membranes. The binding is stereospecific,(+)-
nicotine being 57 times less potent than (-)-nicotine in displacing labeled (+/-)-nicotine …