Multiple neurotransmitter systems are affected in senile dementia of the Alzheimer's type
(SDAT). Among them, acetylcholine has been most studied. It is now well accepted that the …

The anterio-posterior distribution of cholinergic receptor binding sites in human
hippocampus (five parts) as well as the effect of age (age range 3 days-85 years) on …

Abstract Whitehouse, Peter J. and Kin Sing Au: Cholinergic receptors in aging and
Alzheimer's disease. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1986, 10 (3–5): 665 …

The topographical distribution of [α:12T] bungarotoxin [125I] BTX,[3H] nicotine ([3H]
Nic),[3H] acetylcholine ([3H] ACh)(in the presence of atropine) binding in rat teland …

Abstract Saline, 8.0 mg/kg/hr nicotine, or 1.0 mg/kg/hr oxotremorine was continously infused
into the jugular veins of DBA female mice. After 10 days of treatment, respiratory rate …

Publisher Summary This chapter discusses the role of nicotinic receptors in the
pathophysiology of Alzheimer's disease (AD). The nicotinic receptor binding sites in human …

Rats received nicotine (50 mg nicotine base/1) in their drinking fluid for 28 days. The daily
consumption of nicotine was about 4 mg/kg per day. Controls received plain water. Body …

The postnatal development of the cholinergic neurotransmitter system was studied in the
cortex, hippocampus, midbrain and cerebellum of 3-, 7-, 12-, 17-and 30-day-old NMRI mice …

The paradoxical status of the pharmacology of nicotinic mechanisms as a research problem
has both stimulated and frustrated psychopharmacologists. The paradox is the dissonance …

Publisher Summary The central effects of nicotine are mainly due to its interaction with
specific brain receptors. Their stimulation increases the firing rate of many neurons and …