Ovarian aging refers to the process by which ovarian function declines until eventual failure.
The pathogenesis of ovarian aging is complex and diverse; oxidative stress (OS) is …

Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

Increasing evidence on the significance of nutrition in reproduction is emerging from both
animal and human studies, suggesting a mutual association between nutrition and female …

The quality and maturation of an oocyte not only play decisive roles in fertilization and
embryo success, but also have long-term impacts on the later growth and development of …

Meiosis, a key process in the creation of haploid gametes, is a complex cellular division
incorporating unique timing and intricate chromosome dynamics. Abnormalities in this …

Mutations in mitochondrial DNA (mtDNA) contribute to multiple diseases. However, how new
mtDNA mutations arise and accumulate with age remains understudied because of the high …

Aging has a major detrimental effect on the optimal function of the ovary with changes in this
organ preceding the age-related deterioration in other tissues, with the middle-aged …

The number of mitochondria in the oocyte along with their functions (eg, energy production,
scavenger activity) decline with age progression. Such multifaceted functions support …

The follicle is the functional unit of the ovary, whereby ovarian development is largely
dependent on the development of the follicles themselves. The activation, growth, and …

Zinc, an essential trace mineral, plays a pivotal role in cell proliferation, maintenance of
redox homeostasis, apoptosis, and aging. Serum zinc concentrations are reduced in …