Most life scientists would agree that understanding how cellular processes work requires
structural knowledge about the macromolecules involved. For example, deciphering the …

Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …

Cryo–electron tomography (cryo-ET) is a powerful method to elucidate subcellular
architecture and to structurally analyze biomolecules in situ by subtomogram averaging, yet …

The focused ion beam (FIB) is a powerful tool for fabrication, modification, and
characterization of materials down to the nanoscale. Starting with the gallium FIB, which was …

To best understand parasite, host, and vector morphologies, host–parasite interactions, and
to develop new drug and vaccine targets, structural data should, ideally, be obtained and …

Evaluating the heterogeneity of extracellular vesicles (EVs) is crucial for unraveling their
complex actions and biodistribution. Here, we identify consistent architectural heterogeneity …

Positive-strand RNA viruses encompass a variety of established and emerging eukaryotic
pathogens. Their genome replication is confined to specialized cytoplasmic membrane …

There is a clear need for developments in characterisation techniques that provide detailed
information about structure–function relationships in biology. Using electron microscopy to …

Networks of solution-processed nanomaterials are becoming increasingly important across
applications in electronics, sensing and energy storage/generation. Although the physical …

Cryo-electron tomography and subtomogram averaging are rising and fast-evolving imaging
techniques to study biological events, providing structural information at an unprecedented …