The brain can represent behaviorally relevant information through the firing of individual
neurons as well as the coordinated firing of ensembles of neurons. Neurons in the …

For decades, the mammalian hippocampus has been the focus of cellular, anatomical,
behavioral, and computational studies aimed at understanding the fundamental …

Decision-making requires flexibility to rapidly switch one's actions in response to sensory
stimuli depending on information stored in memory. We identified cortical areas and neural …

Salient cues, such as the rising sun or availability of food, entrain biological clocks for
behavioral adaptation. The mechanisms underlying entrainment to food availability remain …

Activated microglia and subsequent release of pro-inflammatory cytokines result in
neuroinflammatory status which further damage neurological function including cognitive …

Current methods for recording large-scale neuronal activity from behaving mice at single-
cell resolution require either fixing the mouse head under a microscope or attachment of a …

Neuronal activity during experience is thought to induce plastic changes within the
hippocampal network that underlie memory formation, although the extent and details of …

Memories are encoded by sparse populations of neurons but how such sparsity arises
remains largely unknown. We found that a neuron's eligibility to be recruited into the memory …

Memory consolidation involves discrete patterns of transcriptional events in the
hippocampus. Despite the emergence of single-cell transcriptomic profiling techniques …

The representation of distinct spaces by hippocampal place cells has been linked to
changes in their place fields (the locations in the environment where the place cells …