Objective X‐linked adrenoleukodystrophy (ALD) is a neurodegenerative disorder due to
mutations in the peroxisomal very long‐chain fatty acyl‐CoA transporter, ABCD1, with …

Very long-chain fatty acids (VLCFAs) are degraded exclusively in peroxisomes, as
evidenced by the accumulation of VLCFAs in patients with certain peroxisomal disorders …

X-linked adrenoleukodystrophy (ALD) is a genetic disorder that presents neurologically as
either a rapid and fatal cerebral demyelinating disease in childhood (childhood cerebral …

Aberrant endocannabinoid signaling accompanies several neurodegenerative disorders,
including multiple sclerosis. Here, we report altered endocannabinoid signaling in X-linked …

Redox imbalance, mitochondrial dysfunction, and inflammation play a major role in the
pathophysiology of X-linked adrenoleukodystrophy (X-ALD), an inherited …

Epilepsy is a chronic neurological disease with recurrent seizures. Increasing evidence
suggests that endoplasmic reticulum (ER) stress may play a role in the pathogenesis of …

Abstract X-linked adrenoleukodystrophy (X-ALD) is an inherited neurodegenerative disorder
associated with mutations of the ABCD1 gene that encodes a peroxisomal transmembrane …

Proteostasis failure is a common pathological characteristic in neurodegenerative diseases.
Revitalizing clearance systems could effectively mitigate these diseases. The transactivation …

The peroxisomal disease adrenoleukodystrophy (X-ALD) is caused by loss of the transporter
of very-long-chain fatty acids (VLCFAs), ABCD1. An excess of VLCFAs disrupts essential …

Aims Mitochondrial dysfunction and inflammation are at the core of axonal degeneration in
several multifactorial neurodegenerative diseases, including multiple sclerosis, Alzheimer's …