The availability of the results of high-throughput analyses coming from 'omic'technologies
has been one of the major driving forces of pathway biology. Analytical pathway biology …

Omics approaches to the study of complex biological systems with potential applications to
molecular medicine are attracting great interest in clinical as well as in basic biological …

This review describes two mathematical approaches useful for decoding the complex signal
of 2D-PAGE maps of protein mixtures. These methods are helpful for interpreting the large …

One of the challenges of current proteomics research is identifying healthy and diseased
mass spectrometric (MS) patterns within biological fluids. As a result, sample preparation …

Patients with cancer produce specific autoantibodies against protein antigens present in
limited amount among a large background of immunoglobulins (Igs), nonrelevant as …

Abstract Diabetes mellitus type 1 (DM1) is a major public health problem that continues to
burden the healthcare systems worldwide, costing exponentially more as the epidemic …

PURPOSE OF REVIEW: The understanding of heart failure syndrome is increased and the
interpretation of the related underlying mechanisms is improved by the integrated molecular …

Mycobacterial infections are one of the deadliest infectious diseases still posing a major
health burden worldwide. The battle against these pathogens needs to focus on novel …

Eur J Clin Invest 2011; 41 (12): 1275–1283 Abstract Background Childhood obesity
represents one of the most challenging health problems of our century and is associated …

Several human activities such as urbanization, industrialization, mining activities,
agricultural activities, and even transportation lead to the spread and accumulation of many …