With over a billion adults worldwide currently affected, presbyopia remains a ubiquitous,
global problem. Despite over a century of study, the precise mechanism of ocular …

Cataract is a leading ocular disease causing global blindness. The mechanism of
cataractogenesis has not been well defined. Here, we demonstrate that the heat shock …

Cataract disease is strongly associated with progressively accumulating oxidative damage
to the extremely long-lived crystallin proteins of the lens. Cysteine oxidation affects crystallin …

Vertebrate eye lenses are uniquely adapted to form a refractive index gradient (GRIN) for
improved acuity, and to grow slowly in size despite constant cell proliferation. The …

The ocular lens is an important determinant of overall vision quality whose refractive and
transparent properties change throughout life. The lens operates an internal microcirculation …

Objective To determine whether there is a causal relationship between thyroid dysfunction
and the risk of age-related cataract (ARC) in the European population. Design A two-sample …

Age-related cataract (ARC) is the predominant cause of global blindness, linked to the
progressive aging of the lens, oxidative stress, perturbed calcium homeostasis, hydration …

In mice, the contraction of the ciliary muscle via the administration of pilocarpine reduces the
zonular tension applied to the lens and activates the TRPV1-mediated arm of a dual …

The aim of this study was to compare the visual outcomes of patients who underwent
phacoemulsification surgery and received either trifocal or extended depth-of-focus (EDOF) …