Synthesis, reactions and application of chalcones: A systematic review

MA Shalaby, SA Rizk, AM Fahim - Organic & Biomolecular Chemistry, 2023 - pubs.rsc.org
Chalcones are a group of naturally occurring compounds that have biological effects that
include anti-inflammatory, anti-cancer, and antibacterial properties. Current chalcone …

[HTML][HTML] Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2

CMC Andrés, JM Pérez de la Lastra… - International Journal of …, 2024 - mdpi.com
The phrase “Let food be thy medicine…” means that food can be a form of medicine and
medicine can be a form of food; in other words, that the diet we eat can have a significant …

Nature as a source and inspiration for human monoamine oxidase B (hMAO-B) inhibition: A review of the recent advances in chemical modification of natural …

F Melfi, S Carradori, A Angeli… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction Over the past 5 years, we have witnessed intense research activity about the
biological potential of natural products (NPs) as human monoamine oxidase B (hMAO-B) …

[HTML][HTML] Hydroxy chalcones and analogs with chemopreventive properties

ML Birsa, LG Sarbu - International Journal of Molecular Sciences, 2023 - mdpi.com
The aim of this review is to highlight the chemopreventive properties of hydroxy-substituted
natural and synthetic chalcones along with a number of their analogs. These products …

Design and synthesis of novel imidazole-chalcone derivatives as microtubule protein polymerization inhibitors to treat cervical cancer and reverse cisplatin resistance

Z Liu, Z Yang, M Ablise - Bioorganic Chemistry, 2024 - Elsevier
Using the licochalcone moiety as a lead compound scaffold, 16 novel imidazole-chalcone
derivatives were designed and synthesized as microtubule protein polymerization inhibitors …

Design, Synthesis, and Anti-Breast Cancer Potential of Imidazole–Pyridine Hybrid Molecules In Vitro and Ehrlich Ascites Carcinoma Growth Inhibitory Activity …

B Aruchamy, MG Kuruburu, VR Bovilla… - ACS …, 2023 - ACS Publications
Breast cancer remains a challenging medical issue and is a high priority for biomedical
research despite significant advancements in cancer research and therapy. The current …

[HTML][HTML] Synthesis, α-Glucosidase Inhibitory Activity and Molecular Docking Study of Chalcone Derivatives Bearing a 1H-1, 2, 3-Triazole Unit

B Ardiansah, N Rohman, MAF Nasution… - Chemical and …, 2023 - jstage.jst.go.jp
Diabetes mellitus (DM) is a metabolic condition that is a major health concern around the
world. The current study investigates the synthesis of a series of chalcone and 1H-1, 2, 3 …

[HTML][HTML] Quinoline-and Isoindoline-Integrated Polycyclic Compounds as Antioxidant, and Antidiabetic Agents Targeting the Dual Inhibition of α-Glycosidase and α …

M Al-Ghorbani, O Alharbi, AB Al-Odayni, NAY Abduh - Pharmaceuticals, 2023 - mdpi.com
Novel analogs of quinoline and isoindoline containing various heterocycles, such as
tetrazole, triazole, pyrazole, and pyridine, were synthesized and characterized using FT-IR …

[HTML][HTML] Development of Orally Active Anti-Inflammatory Agents: In Vivo and In Silico Analysis of Naphthalene-Chalcone Derivatives Based on 2-Acetyl-6-Methoxy …

D Vasudha, A Jagadeesh, SK Konidala, H Yasin… - Chemical Physics …, 2024 - Elsevier
Chalcone compounds are reported to have diverse biological activities such as antiviral,
antimicrobial, antimalarial, antitumor, antifungal, anticancer, and so forth. Herewith, we wish …

[HTML][HTML] Mitochondrial Role in Intrinsic Apoptosis Induced by a New Synthesized Chalcone in Hepatocellular Carcinoma Cells

A Santarsiero, I Pappalardo, GM Rosa, I Pisano… - Biomedicines, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the fourth
cause of cancer-related deaths worldwide. Presently, a few drugs are available for HCC …