This contribution examines the current role that polymeric systems have in controlling the
administration and site-specific delivery of drugs. The fundamentals of polymeric controlled …

Plasma concentrations of levonorgestrel, progesterone, estradiol, FSH and LH were
measured in seven volunteers who had a levonorgestrel-releasing IUD inserted …

Biomedical engineering approaches used to develop controlled-release delivery systems for
hormones are here reviewed regarding system design and therapeutic applications. The …

Patterns of bleeding and plasma concentrations of levonorgestrel, progesterone, estradiol,
LH and FSH were studied in ten volunteers who had a levonorgestrel-releasing IUD inserted …

Recognition of the sustained vigilance required for most methods of successful
contraception has stimulated attention to dosage forms that can deliver appropriate …

A levonorgestrel-releasing intracervical device (ICD) was inserted postmenstrually to twenty-
one voluntary women. Eight subjects gave blood samples twice a week during the initial …

One Silastik R capsule of 15 mm, 20 mm or 30 mm length was inserted subcutaneously into
the ventral aspect of the left forearm or upper arm of 28 healthy women during menstrual …

Seven women used an ST-1435-releasing intracervical contraceptive device (ST-ICD),
inserted immediately after the cessation of menstrual bleeding. Patterns of bleeding and …

Post-menopausal patients were treated with a new form of oestrogen administration by
using two types of oestrone-containing vaginal rings. It was observed that oestrone was …

Six Silastic R levonorgestrel-releasing capsules, Norplant R, were introduced
subcutaneously into the ventral aspect of the left forearm or upper arm of thirteen patients …