Sporadic Parkinson's disease (PD) is a progressive neurodegenerative disease, with a
complex risk structure thought to be influenced by interactions between genetic variants and …

Abstract N6-methyladenosine (m6A) is a dynamic reversible methylation modification of the
adenosine N6 position and is the most common chemical epigenetic modification among …

One-carbon metabolism (OCM) is a network of biochemical reactions delivering one-carbon
units to various biosynthetic pathways. The folate cycle and methionine cycle are the two key …

Evidence for epigenetic regulation playing a role in Parkinson's disease (PD) is growing,
particularly for DNA methylation. Approximately 90% of PD cases are due to a complex …

In addition to immune cells and fibroblasts, the tumor microenvironment (TME) comprises an
extracellular matrix (ECM) which contains collagens (COLs) whose architecture and …

Parkinson's disease (PD) is a neurodegenerative disorder with a complex etiology and
increasing prevalence worldwide. As PD is influenced by a combination of genetic and …

Parkinson's disease (PD) is the second most common neurodegenerative disease in the
United States. Decades before motor symptoms manifest, non-motor symptoms such as …

Prion diseases are transmissible spongiform encephalopathies (TSEs) caused by a
conformational conversion of the native cellular prion protein (PrPC) to an abnormal …

Background: Earlier studies reported alterations of the kynurenine (KYN) pathway of
tryptophan (TRP) metabolism in Parkinson's disease (PD). The first rate-limiting enzymes …

Parkinson's disease (PD) is a common neurodegenerative disorder caused by genetic,
epigenetic, and environmental factors. Recent advance in genomics and epigenetics have …