Therapeutic implications of menin inhibition in acute leukemias
GC Issa, F Ravandi, CD DiNardo, E Jabbour… - Leukemia, 2021 - nature.com
Menin inhibitors are novel targeted agents currently in clinical development for the treatment
of genetically defined subsets of acute leukemia. Menin has a tumor suppressor function in …
of genetically defined subsets of acute leukemia. Menin has a tumor suppressor function in …
Current status and future perspectives in targeted therapy of NPM1-mutated AML
Abstract Nucleophosmin 1 (NPM1) is a nucleus-cytoplasmic shuttling protein which is
predominantly located in the nucleolus and exerts multiple functions, including regulation of …
predominantly located in the nucleolus and exerts multiple functions, including regulation of …
Mutant NPM1 directly regulates oncogenic transcription in acute myeloid leukemia
HJ Uckelmann, EL Haarer, R Takeda, EM Wong… - Cancer discovery, 2023 - AACR
The dysregulation of developmental and stem cell–associated genes is a common
phenomenon during cancer development. Around half of patients with acute myeloid …
phenomenon during cancer development. Around half of patients with acute myeloid …
Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
Abstract Treatment with Menin inhibitor (MI) disrupts the interaction between Menin and
MLL1 or MLL1-fusion protein (FP), inhibits HOXA9/MEIS1, induces differentiation and loss of …
MLL1 or MLL1-fusion protein (FP), inhibits HOXA9/MEIS1, induces differentiation and loss of …
Proteomic and phosphoproteomic landscapes of acute myeloid leukemia
MH Kramer, Q Zhang, R Sprung, RB Day… - Blood, The Journal …, 2022 - ashpublications.org
We have developed a deep-scale proteome and phosphoproteome database from 44
representative acute myeloid leukemia (AML) patients from the LAML TCGA dataset and 6 …
representative acute myeloid leukemia (AML) patients from the LAML TCGA dataset and 6 …
Deep learning detects acute myeloid leukemia and predicts NPM1 mutation status from bone marrow smears
The evaluation of bone marrow morphology by experienced hematopathologists is essential
in the diagnosis of acute myeloid leukemia (AML); however, it suffers from a lack of …
in the diagnosis of acute myeloid leukemia (AML); however, it suffers from a lack of …
Small-molecule inhibition of the acyl-lysine reader ENL as a strategy against acute myeloid leukemia
The chromatin reader eleven–nineteen leukemia (ENL) has been identified as a critical
dependency in acute myeloid leukemia (AML), but its therapeutic potential remains unclear …
dependency in acute myeloid leukemia (AML), but its therapeutic potential remains unclear …
A concise review on the molecular genetics of acute myeloid leukemia
D Padmakumar, VR Chandraprabha, P Gopinath… - Leukemia Research, 2021 - Elsevier
Acute myeloid leukemia (AML) is the most common acute leukemia in adults that affects the
myeloid lineage. The recent advances have upgraded our understanding of the cytogenetic …
myeloid lineage. The recent advances have upgraded our understanding of the cytogenetic …
Homeobox genes in cancers: from carcinogenesis to recent therapeutic intervention
Y Feng, T Zhang, Y Wang, M Xie, X Ji, X Luo… - Frontiers in …, 2021 - frontiersin.org
The homeobox (HOX) genes encoding an evolutionarily highly conserved family of
homeodomain-containing transcriptional factors are essential for embryogenesis and …
homeodomain-containing transcriptional factors are essential for embryogenesis and …
Mutant NPM1 hijacks transcriptional hubs to maintain pathogenic gene programs in acute myeloid leukemia
Nucleophosmin (NPM1) is a ubiquitously expressed nucleolar protein with a wide range of
biological functions. In 30% of acute myeloid leukemia (AML), the terminal exon of NPM1 is …
biological functions. In 30% of acute myeloid leukemia (AML), the terminal exon of NPM1 is …