Background and objective: We explored which clinical and biochemical variables predict
conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis …

Each year about 650,000 Europeans die from stroke and a similar number lives with the
sequelae of multiple sclerosis (MS). Stroke and MS differ in their etiology. Although cause …

A prodrome is an early set of signs or symptoms that indicate the onset of a disease before
more typical symptoms develop. Prodromal stages are well recognized in some neurological …

Background Quantitative in vivo imaging of myelin loss and repair in patients with multiple
sclerosis (MS) is essential to understand the pathogenesis of the disease and to evaluate …

Objectives Currently, multiple sclerosis is treated with anti-inflammatory therapies, but these
treatments lack efficacy in progressive disease. New treatment strategies aim to repair …

Multiple sclerosis (MS) has a strong racial and ethnic component and disproportionately
affects whites of European background. Recent incidence reports suggest an increasing rate …

Using the Illumina 450K array and a stringent statistical analysis with age and gender
correction, we report genome-wide differences in DNA methylation between pathology-free …

Summary Background HLA-DRB1* 15 genotype, previous infection with Epstein-Barr virus,
and vitamin D insufficiency are susceptibility factors for multiple sclerosis, but whether they …

Acquiring the recommended daily allowance of vitamins is crucial for maintaining
homeostatic balance in humans and other animals. A deficiency in or dysregulation of …

Multiple sclerosis (MS) is an inflammatory and neurodegenerative demyelinating disease of
the central nervous system (CNS), most likely autoimmune in origin, usually beginning in …