Cardiovascular Diseases (CVDs) are the leading cause of death globally. More than 17
million people die worldwide from CVD per year. There is considerable evidence suggesting …

Recent clinical and experimental studies are redefining the cellular and molecular bases of
pulmonary arterial hypertension (PAH). The genetic abnormalities first identified in …

Sex differences in the anatomy and physiology of the respiratory system have been widely
reported. These intrinsic sex differences have also been shown to modulate the …

Autophagy is a reparative, life-sustaining process by which cytoplasmic components are
sequestered in double-membrane vesicles and degraded on fusion with lysosomal …

Pregnancy outcomes in patients with pulmonary hypertension remain poor despite
advanced therapies. Although consensus guidelines recommend against pregnancy in …

Pulmonary hypertension (PH) encompasses a syndrome of diseases that are characterized
by elevated pulmonary artery pressure and pulmonary vascular remodeling and that …

Women with pulmonary arterial hypertension (PAH) exhibit better right ventricular (RV)
function and survival than men; however, the underlying mechanisms are unknown. We …

Cardiovascular diseases are one of the leading causes of death. Increasing evidence has
shown that pharmacological or genetic targeting of mitochondria can ameliorate each stage …

Rationale: Pulmonary arterial hypertension (PH) is a life-threatening condition associated
with immune dysregulation and abnormal regulatory T cell (Treg) activity, but it is currently …

Abstract Swenson, Erik R. Hypoxic pulmonary vasoconstriction. High Alt Med Biol 14: 101–
110, 2013.—Hypoxic pulmonary vasoconstriction (HPV) continues to fascinate …