Epigenetic mechanisms as emerging therapeutic targets and microfluidic chips application in pulmonary arterial hypertension

L Ho, N Hossen, T Nguyen, A Vo, F Ahsan - Biomedicines, 2022 - mdpi.com
Pulmonary arterial hypertension (PAH) is a disease that progress over time and is defined
as an increase in pulmonary arterial pressure and pulmonary vascular resistance that …

Estrogen maintains mitochondrial content and function in the right ventricle of rats with pulmonary hypertension

A Liu, J Philip, KC Vinnakota… - Physiological …, 2017 - Wiley Online Library
The typical cause of death in pulmonary hypertension (PH) is right ventricular (RV) failure,
with females showing better survival rates than males. Recently, metabolic shift and …

Role of miR‐21‐5p/FilGAP axis in estradiol alleviating the progression of monocrotaline‐induced pulmonary hypertension

X Hu, Q Wang, H Zhao, W Wu, Q Zhao… - Animal Models and …, 2022 - Wiley Online Library
Background Aberrant expression of microRNAs (miRNAs) has been associated with the
pathogenesis of pulmonary hypertension (PH). It is, however, not clear whether miRNAs are …

The role of sex in the pathophysiology of pulmonary hypertension

CK Docherty, KY Harvey, KM Mair, S Griffin… - Sex-Specific Analysis of …, 2018 - Springer
Pulmonary arterial hypertension (PAH) is a progressive disease characterised by increased
pulmonary vascular resistance and pulmonary artery remodelling as result of increased …

Aqp-1 Gene Knockout Attenuates Hypoxic Pulmonary Hypertension of Mice

M Liu, Q Liu, Y Pei, M Gong, X Cui, J Pan… - … , and vascular biology, 2019 - Am Heart Assoc
Objective—Hypoxic pulmonary hypertension (HPH) is characterized by proliferative vascular
remodeling. Abnormal pulmonary artery smooth muscle cells proliferation and endothelial …

[HTML][HTML] Sex differences, estrogen metabolism and signaling in the development of pulmonary arterial hypertension

Y Sun, S Sangam, Q Guo, J Wang, H Tang… - Frontiers in …, 2021 - frontiersin.org
Pulmonary arterial hypertension (PAH) is a complex and devastating disease with a poor
long-term prognosis. While women are at increased risk for developing PAH, they exhibit …

Sinus venosus adaptation models prolonged cardiovascular disease and reveals insights into evolutionary transitions of the vertebrate heart

JT Gafranek, E D'Aniello, P Ravisankar… - Nature …, 2023 - nature.com
How two-chambered hearts in basal vertebrates have evolved from single-chamber hearts
found in ancestral chordates remains unclear. Here, we show that the teleost sinus venosus …

Estrogen receptor-α prevents right ventricular diastolic dysfunction and fibrosis in female rats

TC Cheng, JL Philip, DM Tabima… - American Journal …, 2020 - journals.physiology.org
Although women are more susceptible to pulmonary arterial hypertension (PAH) than men,
their right ventricular (RV) function is better preserved. Estrogen receptor-α (ERα) has been …

Anesthesia for pregnant women with pulmonary hypertension

S Rex, S Devroe - Current Opinion in Anesthesiology, 2016 - journals.lww.com
Anesthesiologists involved in the management of pregnant patients with pulmonary
hypertension must have detailed knowledge of pathophysiological alterations in pregnancy …

Sex differences in the pulmonary circulation: implications for pulmonary hypertension

YN Martin, CM Pabelick - American Journal of Physiology …, 2014 - journals.physiology.org
Pulmonary arterial hypertension (PAH), a form of pulmonary hypertension, is a complex
disease of multifactorial origin. While new developments regarding pathophysiological …