One of the most recent trends in cardiac electrophysiology is the development of integrative
anatomically accurate models of the heart, which include description of cardiac activity from …

In this work, a parallel three-dimensional solver for numerical simulations in computational
electrocardiology is introduced and studied. The solver is based on the anisotropic …

Many problems in Biology and Engineering are governed by anisotropic reaction–diffusion
equations with a very rapidly varying reaction term. This usually implies the use of very fine …

The VPH/Physiome Project is developing the model encoding standards CellML (cellml. org)
and FieldML (fieldml. org) as well as web-accessible model repositories based on these …

In this paper we present a numerical method for the bidomain model, which describes the
electrical activity in the heart. The model consists of two partial differential equations (PDEs) …

We studied the stability of spiral waves in homogeneous two-dimensional cardiac tissue
using phase I of the Luo–Rudy ventricular action potential model. By changing the …

Recent experimental and theoretical results have stressed the importance of modeling
studies of reentrant arrhythmias in cardiac tissue and at the whole heart level. We introduce …

In this study, the feasibility of conducting in silico experiments in near-realtime with
anatomically realistic, biophysically detailed models of human cardiac electrophysiology is …

Spatially discordant alternans, where the action potential duration (APD) and intracellular
calcium transient (Cai) alternate with opposite phase in different regions of tissue, is known …

Scroll wave (vortex) breakup is hypothesized to underlie ventricular fibrillation, the leading
cause of sudden cardiac death. We simulated scroll wave behaviors in a three-dimensional …