Microfluidic modelling of the tumor microenvironment for anti-cancer drug development
Cancer is the leading cause of death worldwide. The complex and disorganized tumor
microenvironment makes it very difficult to treat this disease. The most common in vitro drug …
microenvironment makes it very difficult to treat this disease. The most common in vitro drug …
Breast cancer models: Engineering the tumor microenvironment
The mechanisms behind cancer initiation and progression are not clear. Therefore,
development of clinically relevant models to study cancer biology and drug response in …
development of clinically relevant models to study cancer biology and drug response in …
Nanofiber membrane supported lung-on-a-chip microdevice for anti-cancer drug testing
X Yang, K Li, X Zhang, C Liu, B Guo, W Wen, X Gao - Lab on a Chip, 2018 - pubs.rsc.org
Organ-on-a-chip technology can simulate the physiological and pathological
microenvironment of tissues and organs in vitro, thus offering the potential of dispensing with …
microenvironment of tissues and organs in vitro, thus offering the potential of dispensing with …
[HTML][HTML] Engineering prostate cancer in vitro: what does it take?
A key challenge in the clinical management and cause of treatment failure of prostate cancer
(PCa) is its molecular, cellular and clinical heterogeneity. Modelling systems that fully …
(PCa) is its molecular, cellular and clinical heterogeneity. Modelling systems that fully …
Extracellular matrix remodeling and stiffening modulate tumor phenotype and treatment response
Solid tumors are characterized by a remodeled and stiffened extracellular matrix. The
extracellular matrix is not a passive by-product of the tumor, but actively compromises tissue …
extracellular matrix is not a passive by-product of the tumor, but actively compromises tissue …
Exploring the tumor microenvironment with nanoparticles
Recent developments in nanotechnology have brought new approaches to cancer
diagnosis and therapy. While enhanced permeability and retention effect (EPR) promotes …
diagnosis and therapy. While enhanced permeability and retention effect (EPR) promotes …
The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics
Prostate cancer bone metastases are a leading cause of cancer-related death in men with
current treatments offering only marginally improved rates of survival. Advances in the …
current treatments offering only marginally improved rates of survival. Advances in the …
[HTML][HTML] Proteomic profiling of human prostate Cancer-associated fibroblasts (CAF) reveals LOXL2-dependent regulation of the tumor microenvironment*[S]
In prostate cancer, cancer-associated fibroblasts (CAF) exhibit contrasting biological
properties to non-malignant prostate fibroblasts (NPF) and promote tumorigenesis …
properties to non-malignant prostate fibroblasts (NPF) and promote tumorigenesis …
Preclinical models of prostate cancer: patient-derived xenografts, organoids, and other explant models
GP Risbridger, R Toivanen… - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
Prostate cancer remains a lethal disease. Preclinical cancer models that accurately
represent the tumors of the patients they are intended to help are necessary to test potential …
represent the tumors of the patients they are intended to help are necessary to test potential …
In vitro modeling of mechanics in cancer metastasis
A Malandrino, RD Kamm… - ACS biomaterials science …, 2018 - ACS Publications
In addition to a multitude of genetic and biochemical alterations, abnormal morphological,
structural, and mechanical changes in cells and their extracellular environment are key …
structural, and mechanical changes in cells and their extracellular environment are key …