Validity of the Symbol Digit Modalities Test as a cognition performance outcome measure for multiple sclerosis

RHB Benedict, J DeLuca, G Phillips… - Multiple Sclerosis …, 2017 - journals.sagepub.com
Cognitive and motor performance measures are commonly employed in multiple sclerosis
(MS) research, particularly when the purpose is to determine the efficacy of treatment. The …

Optimizing treatment success in multiple sclerosis

T Ziemssen, T Derfuss, N de Stefano, G Giovannoni… - Journal of …, 2016 - Springer
Despite important advances in the treatment of multiple sclerosis (MS) over recent years, the
introduction of several disease-modifying therapies (DMTs), the burden of progressive …

Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination

T Skripuletz, D Hackstette, K Bauer, V Gudi, R Pul… - Brain, 2013 - academic.oup.com
Recent evidence suggests that astrocytes play an important role in regulating de-and
remyelination in multiple sclerosis. The role of astrocytes is controversial, and both …

Immune-mediated neuropathies

BC Kieseier, EK Mathey, C Sommer… - Nature reviews Disease …, 2018 - nature.com
Since the discovery of an acute monophasic paralysis, later coined Guillain–Barré
syndrome, almost 100 years ago, and the discovery of chronic, steroid-responsive …

Mitoxantrone for multiple sclerosis

FM Boneschi, L Vacchi, M Rovaris… - Cochrane Database …, 2013 - cochranelibrary.com
Mitoxantrone for multiple sclerosis - Martinelli Boneschi, F - 2013 | Cochrane Library Skip to
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The neural androgen receptor: a therapeutic target for myelin repair in chronic demyelination

R Hussain, AM Ghoumari, B Bielecki, J Steibel… - Brain, 2013 - academic.oup.com
Myelin regeneration is a major therapeutic goal in demyelinating diseases, and the failure to
remyelinate rapidly has profound consequences for the health of axons and for brain …

Progesterone and nestorone promote myelin regeneration in chronic demyelinating lesions of corpus callosum and cerebral cortex

M El‐Etr, M Rame, C Boucher, AM Ghoumari, N Kumar… - Glia, 2015 - Wiley Online Library
Multiple Sclerosis affects mainly women and consists in intermittent or chronic damages to
the myelin sheaths, focal inflammation, and axonal degeneration. Current therapies are …

Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more

MC Mayer, E Meinl - Therapeutic advances in neurological …, 2012 - journals.sagepub.com
B cells and antibodies constitute an important element in different inflammatory diseases of
the central nervous system (CNS). Autoantibodies can serve as a biomarker to identify …

Therapeutic decisions in multiple sclerosis: moving beyond efficacy

W Brück, R Gold, BT Lund, C Oreja-Guevara… - JAMA …, 2013 - jamanetwork.com
Several innovative disease-modifying treatments (DMTs) for relapsing-remitting multiple
sclerosis have been licensed recently or are in late-stage development. The molecular …

The evolving mechanisms of action of glatiramer acetate

T Prod'homme, SS Zamvil - Cold Spring …, 2019 - perspectivesinmedicine.cshlp.org
Glatiramer acetate (GA) is a synthetic amino acid copolymer that is approved for treatment of
relapsing remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS). GA …