Discoveries leading to an improved understanding of immune surveillance of the central
nervous system (CNS) have repeatedly provoked dismissal of the existence of immune …

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …

Recent studies indicate that the adaptive immune system plays a role in Lewy body
dementia (LBD). However, the mechanism regulating T cell brain homing in LBD is …

Barriers between circulation and the central nervous system (CNS) play a key role in the
development and modulation of CNS immune responses. Structural variations in the …

Neuroinflammation is the coordinated response of the central nervous system (CNS) to
threats to its integrity posed by a variety of conditions, including autoimmunity, pathogens …

It is uncontested that perivascular spaces play critical roles in maintaining homeostasis and
priming neuroinflammation. However, despite more than a century of intense research on …

Cerebrospinal fluid (CSF) circulation and turnover provides a sink for the elimination of
solutes from the brain interstitium, serving an important homeostatic role for the function of …

In inflammatory CNS conditions such as multiple sclerosis (MS), current options to treat
clinical relapse are limited, and more selective agents are needed. Disruption of the blood …

The central nervous system (CNS) is an immunologically privileged site to which access of
circulating immune cells is tightly controlled by the endothelial blood–brain barrier (BBB; see …

Immune evasion is a hallmark of cancer, enabling tumors to survive contact with the host
immune system and evade the cycle of immune recognition and destruction. Here, we …