Purpose: BRAF is frequently activated by gene fusion or point mutation in pilocytic
astrocytoma, the most common pediatric brain tumor. We investigated the functional effect of …

High-throughput genomic technologies have shed light on the biologic heterogeneity of
several pediatric brain tumors. The biology of the four common pediatric brain tumors …

Abstract Introduction Pediatric pilocytic astrocytomas (PAs) are low grade gliomas and the
most common brain tumors in children. They often represent a therapeutic challenge when …

Abstract Purpose of Review This review will discuss the role of several key players in glioma
classification and biology, namely isocitrate dehydrogenase 1 and 2 (IDH1/2), alpha …

For some, glioma biomarkers have been expected to solve common diagnostic problems in
routine neuropathology service caused by insufficient material, technical shortcomings or …

Recent studies highlight the importance of BRAF alterations resulting in mitogen activated
protein kinase (MAK/ERK) pathway activation in low-grade CNS tumors. We studied 106 low …

The advances of genomewide 'discovery platforms' and the increasing affordability of the
analysis of significant sample sizes have led to the identification of novel mutations in brain …

Background Pediatric low-grade gliomas (pLGGs) are the most common central nervous
system tumor in children, characterized by RAS/MAPK pathway driver alterations. Genomic …

Abstract Purpose: Oncogenic BRAF/Ras or NF1 loss can potentially trigger oncogene-
induced senescence (OIS) through activation of the mitogen-activated protein kinase …

Abstract Background Optic pathway gliomas (OPGs), also known as visual pathway gliomas,
are debilitating tumors that account for 3–5% of all pediatric brain tumors. They are most …