Pathological and molecular advances in pediatric low-grade astrocytoma
FJ Rodriguez, KS Lim, D Bowers… - Annual review of …, 2013 - annualreviews.org
Pediatric low-grade astrocytomas are the most common brain tumors in children. They can
have similar microscopic and clinical features, making accurate diagnosis difficult. For …
have similar microscopic and clinical features, making accurate diagnosis difficult. For …
Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma
AE Eisenhardt, H Olbrich, M Röring… - … journal of cancer, 2011 - Wiley Online Library
Pilocytic astrocytoma (PA) is emerging as a tumor entity with dysregulated
Ras/Raf/MEK/ERK signaling. Common genetic lesions observed in PA, which are linked to …
Ras/Raf/MEK/ERK signaling. Common genetic lesions observed in PA, which are linked to …
Disseminated glioneuronal tumors occurring in childhood: treatment outcomes and BRAF alterations including V600E mutation
AJ Dodgshun, N SantaCruz, J Hwang… - Journal of neuro …, 2016 - Springer
Disseminated glioneuronal tumors of childhood are rare. We present a retrospective IRB-
approved review of the clinical course and frequency of BRAF mutations in disseminated …
approved review of the clinical course and frequency of BRAF mutations in disseminated …
The power of human cancer genetics as revealed by low-grade gliomas
DTW Jones, P Bandopadhayay… - Annual review of …, 2019 - annualreviews.org
The human brain contains a vast number of cells and shows extraordinary cellular diversity
to facilitate the many cognitive and automatic commands governing our bodily functions …
to facilitate the many cognitive and automatic commands governing our bodily functions …
An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice
J Gronych, A Korshunov, J Bageritz… - The Journal of …, 2011 - Am Soc Clin Investig
Pilocytic astrocytoma (PA) is the most common type of primary brain tumor in children and
the second most frequent cancer in childhood. Children with incompletely resected PA …
the second most frequent cancer in childhood. Children with incompletely resected PA …
In vivo models of brain tumors: roles of genetically engineered mouse models in understanding tumor biology and use in preclinical studies
I Simeonova, E Huillard - Cellular and Molecular Life Sciences, 2014 - Springer
Although our knowledge of the biology of brain tumors has increased tremendously over the
past decade, progress in treatment of these deadly diseases remains modest. Developing in …
past decade, progress in treatment of these deadly diseases remains modest. Developing in …
BRAF Duplications and MAPK Pathway Activation Are Frequent in Gliomas of the Optic Nerve Proper
FJ Rodriguez, AH Ligon… - … of Neuropathology & …, 2012 - academic.oup.com
Optic pathway gliomas represent a specific subtype of astrocytoma with unique
clinicopathologic and biologic properties, but studies of tumors in the optic nerve proper …
clinicopathologic and biologic properties, but studies of tumors in the optic nerve proper …
Molecular markers of glioma: an update on recent progress and perspectives
K Gupta, P Salunke - Journal of cancer research and clinical oncology, 2012 - Springer
Background Significant progress has been made in the molecular diagnostic subtyping of
brain tumors especially gliomas. Designing effective tailored therapy remains the …
brain tumors especially gliomas. Designing effective tailored therapy remains the …
Outcome analysis of childhood pilocytic astrocytomas: a retrospective study of 148 cases at a single institution
C Colin, L Padovani, C Chappé… - Neuropathology and …, 2013 - Wiley Online Library
Background Pilocytic astrocytomas (PAs) are characterized by an excellent prognosis
although several factors of adverse outcome have been reported. The mitogenactivated …
although several factors of adverse outcome have been reported. The mitogenactivated …
Multiplex detection of pediatric low-grade glioma signature fusion transcripts and duplications using the NanoString nCounter system
S Ryall, A Arnoldo, R Krishnatry, M Mistry… - … of Neuropatholgy & …, 2017 - academic.oup.com
Previous studies identified recurrent fusion and duplication events in pediatric low-grade
glioma (pLGG). In addition to their role in diagnosis, the presence of these events aid in …
glioma (pLGG). In addition to their role in diagnosis, the presence of these events aid in …