Pediatric low-grade astrocytomas are the most common brain tumors in children. They can
have similar microscopic and clinical features, making accurate diagnosis difficult. For …

Pilocytic astrocytoma (PA) is emerging as a tumor entity with dysregulated
Ras/Raf/MEK/ERK signaling. Common genetic lesions observed in PA, which are linked to …

Disseminated glioneuronal tumors of childhood are rare. We present a retrospective IRB-
approved review of the clinical course and frequency of BRAF mutations in disseminated …

The human brain contains a vast number of cells and shows extraordinary cellular diversity
to facilitate the many cognitive and automatic commands governing our bodily functions …

Pilocytic astrocytoma (PA) is the most common type of primary brain tumor in children and
the second most frequent cancer in childhood. Children with incompletely resected PA …

Although our knowledge of the biology of brain tumors has increased tremendously over the
past decade, progress in treatment of these deadly diseases remains modest. Developing in …

Optic pathway gliomas represent a specific subtype of astrocytoma with unique
clinicopathologic and biologic properties, but studies of tumors in the optic nerve proper …

Background Significant progress has been made in the molecular diagnostic subtyping of
brain tumors especially gliomas. Designing effective tailored therapy remains the …

Background Pilocytic astrocytomas (PAs) are characterized by an excellent prognosis
although several factors of adverse outcome have been reported. The mitogenactivated …

Previous studies identified recurrent fusion and duplication events in pediatric low-grade
glioma (pLGG). In addition to their role in diagnosis, the presence of these events aid in …