Diabetes shortens the life expectancy by more than a decade, and the excess mortality in
diabetes is correlated with the incidence of kidney disease. Diabetic kidney disease (DKD) …

Acid-labile subunit (ALS) deficiency (ACLSD) constitutes the first monogenic defect involving
a member of the Insulin-like Growth Factor (IGF) binding protein system. The lack of ALS …

Growth hormone (GH) exerts diverse tissue-specific metabolic effects that are not revealed
by global alteration of GH action. To study the direct metabolic effects of GH in the muscle …

Evidence of the continuous rise of novel doping agents and novel doping strategies calls for
the development of more accurate multi‐target screening methods. Direct multi‐target …

Objective The liver is a central target organ of growth hormone (GH), which stimulates the
synthesis of insulin-like growth factor 1 (IGF1) and affects multiple biochemical pathways. A …

Obesity is associated with reduced spontaneous and stimulated growth hormone (GH)
secretion and basal insulin-like growth factor I (IGF-1) levels—which in turn is associated …

Abstract Objective The GH/IGF-1 axis has important roles in growth and metabolism. GH and
GH receptor (GHR) are active in the central nervous system (CNS) and are crucial in …

Linear growth during childhood is a complex process regulated influenced by genetic,
hormonal, nutritional and environmental factors. Linear growth may be impaired in children …

When mice are subjected to 60% calorie restriction for several days, they lose nearly all of
their body fat. Although the animals lack energy stores, their livers produce enough glucose …

Pituitary hormone deficiency, hypopituitarism, is a dysfunction resulting from numerous
etiologies, which can be complete or partial, and is therefore heterogeneous. This …