Altered adipose tissue may contribute to the longevity of Snell dwarf and growth hormone
receptor (GHR) knock-out mice. We report here that white (WAT) and brown (BAT) fat have …

A multistep signaling cascade originates in brain centers that regulate hypothalamic growth
hormone-releasing hormone (Ghrh) and somatostatin expression levels and release to …

Keratoconus (KC) affects the corneal structure, with thinning and bulging outward into a
conelike shape. Irregular astigmatism and decreased visual acuity appear during puberty …

Hybridization is a common breeding technique that can improve germplasm through
heterosis in aquaculture. However, the regulation of key gene expression, including the …

Metabolic health is characterized by optimal blood glucose, lipids, cholesterol, blood
pressure, and adiposity. Alterations in these characteristics may lead to the development of …

Context: Adult-onset GH deficiency (GHD) increases visceral adiposity and the activity of the
enzyme 11β-hydroxysteroid dehydrogenase, which converts cortisone (E) to cortisol (F) …

Epidermal growth factor receptor (EGFR) signaling has a central role in the regenerative
response of the liver upon injury and is involved in cellular transformation linked to chronic …

Ghrelin is a stomach-derived hormone and a potent appetite stimulant. Ghrelin has recently
harbored interest as a potential regulator of carbohydrate and lipid metabolism in skeletal …

Mathematical modeling has provided quantitative information consistent with experimental
data, greatly improving our understanding of the progression of type 1 and type 2 diabetes …

Juvenile idiopathic arthritis (JIA) represents a chronic, autoimmune, rheumatic
musculoskeletal disease with a diagnosis before 16 years of age. Chronic arthritis is a …