The discovery of leptin, an adipocyte-secreted hormone, set the stage for unraveling the
mechanisms dictating energy homeostasis, revealing adipose tissue as an endocrine …

A report of extended longevity in mice homozygous for a mutation producing growth
hormone (GH) deficiency (Brown-Borg et al., 1996) was quickly followed by the …

Growth hormone (GH) influences adipocyte differentiation, but both stimulatory and
inhibitory effects have been described. Adipose tissue-derived mesenchymal stem cells (AT …

Background The main components of GH/insulin-like growth factor (IGF)-1 axis and Sirtuin 4
(Sirt4), highly expressed in liver and skeletal muscle mitochondria, serve as active …

Objective Many patients with acromegaly, a hormonal disorder with excessive growth
hormone (GH) production, report pain in joints. We undertook this study to characterize the …

Background Sleep‐disordered breathing (SDB) is highly prevalent in individuals with Down
syndrome (DS), who cease growing earlier than individuals without DS. These …

Growth hormone (GH) binds to its receptor (growth hormone receptor [GHR]) to exert its
pleiotropic effects on growth and metabolism. Disrupted GH/GHR actions not only fail growth …

Introduction In the last several decades, fueled by gene knockout and knockdown
techniques, there has been substantial progress in detailing the pathways of …

Neonatal intermittent hypoxia (IH) increases the risk for many morbidities in extremely low
birth weight/gestational age (ELBW/ELGA) neonates with compromised antioxidant systems …

Obesity is a chronic disease with increasing prevalence worldwide. Obesity leads to an
increased risk of heart disease, stroke, and diabetes, as well as endocrine alterations …