Salivary glands that produce and secrete saliva, which is essential for lubrication, digestion,
immunity, and oral homeostasis, consist of diverse cells. The long-term maintenance of …

Our understanding of the molecular events underpinning the development of mammalian
organ systems has been increasing rapidly in recent years. With the advent of new and …

Sympathetic activation during cold exposure increases adipocyte thermogenesis via the
expression of mitochondrial protein uncoupling protein 1 (UCP1). The propensity of …

Evolving understanding of structural and biological complexity of tumors has stimulated
development of physiologically relevant tumor models for cancer research and drug …

Insights into the stem cell niche have allowed researchers to cultivate adult tissue stem cells
as organoids that display structural and phenotypic features of healthy and diseased …

Several studies have made strong efforts to understand how age and parity modulate the
risk of breast cancer. A holistic understanding of the dynamic regulation of the …

Patient-derived pancreatic ductal adenocarcinoma (PDAC) organoid systems show great
promise for understanding the biological underpinnings of disease and advancing …

Adult stem cells from a variety of organs can be expanded long-term in vitro as three-
dimensional organotypic structures termed organoids. These adult stem cell-derived …

Advances in stem cell research have enabled the generation of 'mini organs' or organoids
that recapitulate phenotypic traits of the original biological specimen. Although organoids …

Adult mammary stem cells (MaSCs) drive postnatal organogenesis and remodeling in the
mammary gland, and their longevity and potential have important implications for breast …