目的: 本实验拟建立小鼠颌下腺(SMG) 的类器官辐射损伤模型, 为唾液腺辐射损伤修复相关研究
提供模型支持. 方法: 取4 周龄小鼠SMG 组织利用胶原酶消化成单细胞悬液 …

Mouse models have been an invaluable tool to systematically study tumour progression
upon expression of an oncogene or knockdown of tumour suppressors in an immune …

An essential process in predicting the in vivo pharmacological activity of a candidate
molecule involves the evaluation of target responses using established model systems …

The mammary epithelium is indispensable for the continued survival of more than 5000
mammalian species. For some, the volume of milk ejected in a single day exceeds their …

In the past forty years, the WNT/CTNNB1 signaling pathway has emerged as a key player in
mammary gland development and homeostasis. While also evidently involved in breast …

Etablierung von Organoidmodellen und deren Einführung in die gynäkologische
Grundlagenforschung Page 1 Aus der Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe der …

We recently identified TMEM230 as a master regulator of the endomembrane system of
cells. TMEM230 expression is necessary for promoting motor protein dependent intracellular …

A better understanding of the mechanisms generating tumour heterogeneity will allow better
targeting of current therapies, identify potential resistance mechanisms and highlight new …

The orthotopic transplantation assay has provided important insights into mammary
development, stem cell function, and tumorigenesis. Technically, it consists in grafting …

The majority of breast cancer patients receive radiation therapy. Although this treatment
improves overall outcomes, patients with triple negative breast cancer (TNBC) have a …