Calcium (Ca 2+) signals play fundamental roles in immune cell function. The main sources
of Ca 2+ influx in mammalian lymphocytes following antigen receptor stimulation are Ca 2+ …

Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …

Abstract Interleukin-2 (IL-2) is critical for regulatory T cell (Treg) function and homeostasis. At
low doses, IL-2 can suppress immune pathologies by expanding Tregs that constitutively …

CD4+ Th cells are responsible for orchestrating diverse, pathogen-specific immune
responses through their differentiation into a number of subsets, including TH 1, TH 2, TH 9 …

Co-ordinated interaction between distinct cell types is a hallmark of successful immune
function. A striking example of this is the carefully orchestrated cooperation between helper …

T cell help in humoral immunity includes interactions of B cells with activated extrafollicular
CD4+ and follicular T helper (Tfh) cells. Each can promote antibody responses but Tfh cells …

Throughout the last years, gut-resident Foxp3+ regulatory T (Treg) cells have been
associated with a growing number of tissue-specific functions in the intestine, comprising …

Coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is a serious infectious disease that has led to a …

Regulatory T-cells (Treg cells), expressing the transcription factor Foxp3, have an essential
role in the control of immune homeostasis. In order to control diverse types of immune …

Sjögren's syndrome (SjS) is a systemic autoimmune disease marked by xerostomia (dry
mouth), keratoconjunctivitis sicca (eye dryness), and other systematic disorders. Its …