Markers of response for the antiangiogenic agent bevacizumab
D Lambrechts, HJ Lenz, S de Haas… - Journal of Clinical …, 2013 - ascopubs.org
Bevacizumab is the first antiangiogenic therapy proven to slow metastatic disease
progression in patients with cancer. Although it has changed clinical practice, some patients …
progression in patients with cancer. Although it has changed clinical practice, some patients …
[HTML][HTML] CXC family of chemokines as prognostic or predictive biomarkers and possible drug targets in colorectal cancer
S Cabrero-de Las Heras… - World journal of …, 2018 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is the third most common cancer in men and the second most
common cancer in women, worldwide. In the early stages of the disease, biomarkers …
common cancer in women, worldwide. In the early stages of the disease, biomarkers …
[HTML][HTML] Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis
YS Lee, I Choi, Y Ning, NY Kim… - British journal of …, 2012 - nature.com
Background: Colorectal cancer (CRC) is a leading cause of death in the United States.
Increased level of interleukin-8 (IL-8) and CXCR2 on tumours and in the tumour …
Increased level of interleukin-8 (IL-8) and CXCR2 on tumours and in the tumour …
VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials
D Lambrechts, B Claes, P Delmar, J Reumers… - The lancet …, 2012 - thelancet.com
Background No biomarkers that could guide patient selection for treatment with the anti-
VEGF monoclonal antibody bevacizumab have been identified. We assessed whether …
VEGF monoclonal antibody bevacizumab have been identified. We assessed whether …
Cytokine regulation of metastasis and tumorigenicity
The human body combats infection and promotes wound healing through the remarkable
process of inflammation. Inflammation is characterized by the recruitment of stromal cell …
process of inflammation. Inflammation is characterized by the recruitment of stromal cell …
Pharmacogenomics of intrinsic and acquired pharmacoresistance in colorectal cancer: toward targeted personalized therapy
E De Mattia, E Cecchin, G Toffoli - Drug Resistance Updates, 2015 - Elsevier
Colorectal cancer (CRC) represents one of the most common malignancies and is major
cause of cancer-related deaths worldwide. A great improvement in response rate and …
cause of cancer-related deaths worldwide. A great improvement in response rate and …
[HTML][HTML] Endostatin and cancer therapy: a novel potential alternative to anti-VEGF monoclonal antibodies
G Méndez-Valdés, F Gómez-Hevia, J Lillo-Moya… - Biomedicines, 2023 - mdpi.com
Angiogenesis is a physiological process that consists of the formation of new blood vessels
from preexisting ones. Angiogenesis helps in growth, development, and wound healing …
from preexisting ones. Angiogenesis helps in growth, development, and wound healing …
A multiobjective Bayesian networks approach for joint prediction of tumor local control and radiation pneumonitis in nonsmall‐cell lung cancer (NSCLC) for response …
Purpose Individualization of therapeutic outcomes in NSCLC radiotherapy is likely to be
compromised by the lack of proper balance of biophysical factors affecting both tumor local …
compromised by the lack of proper balance of biophysical factors affecting both tumor local …
[HTML][HTML] Targeting tumor cell-derived CCL2 as a strategy to overcome Bevacizumab resistance in ETV5+ colorectal cancer
H Feng, K Liu, X Shen, J Liang, C Wang, W Qiu… - Cell Death & …, 2020 - nature.com
In our previous study, ETV5 mediated-angiogenesis was demonstrated to be dependent
upon the PDGF-BB/PDGFR-β/Src/STAT3/VEGFA pathway in colorectal cancer (CRC) …
upon the PDGF-BB/PDGFR-β/Src/STAT3/VEGFA pathway in colorectal cancer (CRC) …
FOXF1 promotes angiogenesis and accelerates bevacizumab resistance in colorectal cancer by transcriptionally activating VEGFA
S Wang, Z Xiao, Z Hong, H Jiao, S Zhu, Y Zhao, J Bi… - Cancer letters, 2018 - Elsevier
Abstract Forkhead box F1 (FOXF1) has been recently implicated in the progression and
metastasis of lung cancer and breast cancer. However, the biological functions and …
metastasis of lung cancer and breast cancer. However, the biological functions and …