Obesity, diabetes, and related metabolic disorders are major health issues worldwide. As
the epidemic of metabolic disorders continues, the associated medical co-morbidities …

Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …

During mammalian oocyte maturation there are marked changes in the distribution of
mitochondria that supply the majority of the cellular ATP. Such redistribution of mitochondria …

Luteinizing hormone (LH) acts on ovarian follicles to reinitiate meiosis in prophase-arrested
mammalian oocytes, and this has been proposed to occur by interruption of a meioisis …

Mammalian oocytes are long-lived cells in the human body. They initiate meiosis already in
the embryonic ovary, arrest meiotically for long periods in dictyate stage, and resume …

Purpose The number of women attempting to conceive between the ages of 36 and 44 has
increased significantly in the last decade. While it is well established that women's …

A fundamental rule of cell division is that daughter cells inherit half the DNA complement
and an appropriate proportion of cellular organelles. The highly asymmetric cell divisions of …

The NAD+‐dependent sirtuin deacetylase, Sirt1, regulates key transcription factors strongly
implicated in ageing and lifespan. Due to potential confounding effects secondary to loss of …

Metabolic studies of mammalian embryos started with the development of in vitro culture
systems more than 40 years ago. More recently, metabolic studies have begun to shed light …

Mitochondria provide the primary source of ATP in the oocyte and early embryo and
mitochondrial dysfunction and deficit of mitochondria‐derived ATP has been linked to …