Metabolic control of oocyte development: linking maternal nutrition and reproductive outcomes
L Gu, H Liu, X Gu, C Boots, KH Moley… - Cellular and molecular life …, 2015 - Springer
Obesity, diabetes, and related metabolic disorders are major health issues worldwide. As
the epidemic of metabolic disorders continues, the associated medical co-morbidities …
the epidemic of metabolic disorders continues, the associated medical co-morbidities …
The pyruvate dehydrogenase complex: Life's essential, vulnerable and druggable energy homeostat
PW Stacpoole, CE McCall - Mitochondrion, 2023 - Elsevier
Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …
Redistribution of mitochondria leads to bursts of ATP production during spontaneous mouse oocyte maturation
Y Yu, R Dumollard, A Rossbach… - Journal of cellular …, 2010 - Wiley Online Library
During mammalian oocyte maturation there are marked changes in the distribution of
mitochondria that supply the majority of the cellular ATP. Such redistribution of mitochondria …
mitochondria that supply the majority of the cellular ATP. Such redistribution of mitochondria …
Luteinizing hormone causes MAP kinase-dependent phosphorylation and closure of connexin 43 gap junctions in mouse ovarian follicles: one of two paths to meiotic …
Luteinizing hormone (LH) acts on ovarian follicles to reinitiate meiosis in prophase-arrested
mammalian oocytes, and this has been proposed to occur by interruption of a meioisis …
mammalian oocytes, and this has been proposed to occur by interruption of a meioisis …
Age related changes in mitochondrial function and new approaches to study redox regulation in mammalian oocytes in response to age or maturation conditions
U Eichenlaub-Ritter, M Wieczorek, S Lüke, T Seidel - Mitochondrion, 2011 - Elsevier
Mammalian oocytes are long-lived cells in the human body. They initiate meiosis already in
the embryonic ovary, arrest meiotically for long periods in dictyate stage, and resume …
the embryonic ovary, arrest meiotically for long periods in dictyate stage, and resume …
The contribution of mitochondrial function to reproductive aging
Purpose The number of women attempting to conceive between the ages of 36 and 44 has
increased significantly in the last decade. While it is well established that women's …
increased significantly in the last decade. While it is well established that women's …
Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte
CM Dalton, J Carroll - Journal of cell science, 2013 - journals.biologists.com
A fundamental rule of cell division is that daughter cells inherit half the DNA complement
and an appropriate proportion of cellular organelles. The highly asymmetric cell divisions of …
and an appropriate proportion of cellular organelles. The highly asymmetric cell divisions of …
Sirt1 sustains female fertility by slowing age‐related decline in oocyte quality required for post‐fertilization embryo development
JD Iljas, Z Wei, HA Homer - Aging cell, 2020 - Wiley Online Library
The NAD+‐dependent sirtuin deacetylase, Sirt1, regulates key transcription factors strongly
implicated in ageing and lifespan. Due to potential confounding effects secondary to loss of …
implicated in ageing and lifespan. Due to potential confounding effects secondary to loss of …
[PDF][PDF] Metabolism throughout follicle and oocyte development in mammals
E Collado-Fernandez, HM Picton, R Dumollard - Int J Dev Biol, 2012 - researchgate.net
Metabolic studies of mammalian embryos started with the development of in vitro culture
systems more than 40 years ago. More recently, metabolic studies have begun to shed light …
systems more than 40 years ago. More recently, metabolic studies have begun to shed light …
Measurement of ATP in single oocytes: impact of maturation and cumulus cells on levels and consumption
CM Dalton, G Szabadkai… - Journal of cellular …, 2014 - Wiley Online Library
Mitochondria provide the primary source of ATP in the oocyte and early embryo and
mitochondrial dysfunction and deficit of mitochondria‐derived ATP has been linked to …
mitochondrial dysfunction and deficit of mitochondria‐derived ATP has been linked to …