Maternal diabetes causes mitochondrial dysfunction and meiotic defects in murine oocytes
Q Wang, AM Ratchford, MMY Chi… - Molecular …, 2009 - academic.oup.com
The adverse effects of maternal diabetes on embryo development and pregnancy outcomes
have recently been shown to occur as early as the one-cell zygote stage. The hypothesis of …
have recently been shown to occur as early as the one-cell zygote stage. The hypothesis of …
Fertility in women of late reproductive age: the role of serum anti-Müllerian hormone (AMH) levels in its assessment
B Meczekalski, A Czyzyk, M Kunicki… - Journal of …, 2016 - Springer
Introduction Fertility is referred to the capability for having offspring and can be evaluated by
fertility rate. Women's fertility is strictly dependent on individual's age. The fertility peak …
fertility rate. Women's fertility is strictly dependent on individual's age. The fertility peak …
Energy transfer in" parasitic" cancer metabolism: mitochondria are the powerhouse and Achilles' heel of tumor cells
UE Martinez-Outschoorn, RG Pestell, A Howell… - Cell cycle, 2011 - Taylor & Francis
It is now widely recognized that the tumor microenvironment promotes cancer cell growth
and metastasis via changes in cytokine secretion and extracellular matrix remodeling …
and metastasis via changes in cytokine secretion and extracellular matrix remodeling …
Ovarian life cycle
JF Strauss III, CJ Williams - Yen and Jaffe's reproductive endocrinology, 2019 - Elsevier
The ovary is a dynamic organ that undergoes some of the most dramatic changes in
structure and function of any adult human tissue. The follicles are the major endocrine and …
structure and function of any adult human tissue. The follicles are the major endocrine and …
Fatty acid synthesis and oxidation in cumulus cells support oocyte maturation in bovine
L Sanchez-Lazo, D Brisard, S Elis… - Molecular …, 2014 - academic.oup.com
Oocyte meiotic maturation requires energy from various substrates including glucose, amino
acids, and lipids. Mitochondrial fatty acid (FA) β-oxidation (FAO) in the oocyte is required for …
acids, and lipids. Mitochondrial fatty acid (FA) β-oxidation (FAO) in the oocyte is required for …
Association between amino acid turnover and chromosome aneuploidy during human preimplantation embryo development in vitro
HM Picton, K Elder, FD Houghton… - MHR: Basic science …, 2010 - academic.oup.com
This study investigated the relationship between human preimplantation embryo metabolism
and aneuploidy rates during development in vitro. One hundred and eighty-eight fresh and …
and aneuploidy rates during development in vitro. One hundred and eighty-eight fresh and …
Tumor-stroma metabolic relationship based on lactate shuttle can sustain prostate cancer progression
P Sanità, M Capulli, A Teti, GP Galatioto, C Vicentini… - BMC cancer, 2014 - Springer
Background Cancer cell adopts peculiar metabolic strategies aimed to sustain the
continuous proliferation in an environment characterized by relevant fluctuations in oxygen …
continuous proliferation in an environment characterized by relevant fluctuations in oxygen …
Sirt3-dependent deacetylation of SOD2 plays a protective role against oxidative stress in oocytes from diabetic mice
X Liu, L Zhang, P Wang, X Li, D Qiu, L Li, J Zhang… - Cell cycle, 2017 - Taylor & Francis
Maternal diabetes has been demonstrated to adversely affect oocyte quality in mouse
oocytes. However, the potential molecular mechanisms are poorly understood. Here, we …
oocytes. However, the potential molecular mechanisms are poorly understood. Here, we …
[HTML][HTML] Modulating mitochondrial DNA mutations: factors shaping heteroplasmy in the germ line and somatic cells
MR Chiaratti, PF Chinnery - Pharmacological Research, 2022 - Elsevier
Until recently it was thought that most humans only harbor one type of mitochondrial DNA
(mtDNA), however, deep sequencing and single-cell analysis has shown the converse–that …
(mtDNA), however, deep sequencing and single-cell analysis has shown the converse–that …
Mitochondrial dynamics controlled by mitofusins define organelle positioning and movement during mouse oocyte maturation
T Wakai, Y Harada, K Miyado… - Molecular human …, 2014 - academic.oup.com
Mitochondria are abundant in fully grown mammalian oocytes with a unique spherical
morphology, but the mechanisms controlling mitochondria behavior are not well understood …
morphology, but the mechanisms controlling mitochondria behavior are not well understood …