The adverse effects of maternal diabetes on embryo development and pregnancy outcomes
have recently been shown to occur as early as the one-cell zygote stage. The hypothesis of …

Introduction Fertility is referred to the capability for having offspring and can be evaluated by
fertility rate. Women's fertility is strictly dependent on individual's age. The fertility peak …

It is now widely recognized that the tumor microenvironment promotes cancer cell growth
and metastasis via changes in cytokine secretion and extracellular matrix remodeling …

The ovary is a dynamic organ that undergoes some of the most dramatic changes in
structure and function of any adult human tissue. The follicles are the major endocrine and …

Oocyte meiotic maturation requires energy from various substrates including glucose, amino
acids, and lipids. Mitochondrial fatty acid (FA) β-oxidation (FAO) in the oocyte is required for …

This study investigated the relationship between human preimplantation embryo metabolism
and aneuploidy rates during development in vitro. One hundred and eighty-eight fresh and …

Background Cancer cell adopts peculiar metabolic strategies aimed to sustain the
continuous proliferation in an environment characterized by relevant fluctuations in oxygen …

Maternal diabetes has been demonstrated to adversely affect oocyte quality in mouse
oocytes. However, the potential molecular mechanisms are poorly understood. Here, we …

Until recently it was thought that most humans only harbor one type of mitochondrial DNA
(mtDNA), however, deep sequencing and single-cell analysis has shown the converse–that …

Mitochondria are abundant in fully grown mammalian oocytes with a unique spherical
morphology, but the mechanisms controlling mitochondria behavior are not well understood …