Arformoterol and salmeterol in the treatment of chronic obstructive pulmonary disease: a one year evaluation of safety and tolerance

JF Donohue, NA Hanania… - Therapeutic …, 2008 - journals.sagepub.com
Introduction: Concerns have been raised regarding the safety of extended use of long-acting
β 2-agonists (LABAs). The safety of arformoterol (50 µg QD), and salmeterol (42 µg BID) …

Is it asthma or COPD? The answer determines proper therapy for chronic airflow obstruction

FJ Martinez, C Standiford, SE Gay - Postgraduate medicine, 2005 - Taylor & Francis
PREVIEW Evaluation and diagnosis of obstructive lung disease call for careful history taking
to distinguish asthma from chronic obstructive pulmonary disease (COPD). A history of atopy …

Acute bronchodilator responses decline progressively over 4 years in patients with moderate to very severe COPD

DP Tashkin, N Li, EC Kleerup, D Halpin, B Celli… - Respiratory …, 2014 - Springer
Background We previously reported a progressive decline in absolute responses of FEV 1
and FVC to a near-maximal dose of 2 different short-acting bronchodilators over 4 years …

Efficacy of tiotropium bromide (Spiriva®) in patients with chronic obstructive pulmonary disease (COPD) of different severities

KM Beeh, J Beier, R Buhl, P Stark-Lorenzen… - …, 2006 - thieme-connect.com
Background: Aim of this study was to evaluate the efficacy of inhaled tiotropium bromide in
COPD patients of different severities in pneumological practices during a three month …

[HTML][HTML] Tiotropium administered by a pressurized metered dose inhaler (pMDI) and spacer produces a similar bronchodilator response as that administered by a …

B Brashier, P Dhembare, A Jantikar, P Mahadik… - Respiratory …, 2007 - Elsevier
BACKGROUND: Tiotropium is a new long-acting anticholinergic bronchodilator, which is
recommended as first-line therapy in the management of chronic obstructive pulmonary …

The future of combining inhaled drugs for COPD

A Bjerg, B Lundbäck, J Lötvall - Current opinion in pharmacology, 2012 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality
globally, and its prevalence is projected to continue to increase owing to trends in smoking …

Analysis of ADRB2 (Arg16Gly) gene variant with susceptibility, pharmacogenetic response and disease severity in South Indian asthmatics

S Bandaru, J Akka, VK Marri, M Alvala, D Ponnala… - Inflammation, 2015 - Springer
Abstract β2-Adrenergic receptor (β2-AR) plays a crucial role in asthma pathophysiology by
regulating, processes of the lung function, and clinical response to bronchodilators. The+ …

[引用][C] 盐酸戊乙奎醚雾化吸入对慢性阻塞性肺病急性加重期血清TNF-α 和IL-8 的影响

卢惠伦 - 实用医学杂志, 2009

Pharmacokinetic changes of unbound theophylline are due to plasma protein binding displacement and CYP1A2 activity inhibition by baicalin in rats

N Gao, Y Fang, B Qi, L Jia, H Jin, H Qiao - Journal of ethnopharmacology, 2013 - Elsevier
Ethnopharmacological relevance Baicalin is one of the major bioactive constituents of
Scutellariae Radix, the root of Scutellariae baicalensis Georgi and possesses a wide variety …

Screening Ingredients from Herbs against Pregnane X Receptor in the Study of Inductive Herb‐Drug Interactions: Combining Pharmacophore and Docking‐Based …

Z Cui, H Kang, K Tang, Q Liu, Z Cao… - BioMed Research …, 2015 - Wiley Online Library
The issue of herb‐drug interactions has been widely reported. Herbal ingredients can
activate nuclear receptors and further induce the gene expression alteration of drug …