Membrane-bound organelles are a wonderful evolutionary acquisition of the eukaryotic cell,
allowing the segregation of sometimes incompatible biochemical reactions into specific …

The endoplasmic reticulum (ER), mitochondria and lysosomes are physically and/or
functionally linked, establishing close contact sites between these organelles. As a …

In all eukaryotic cells, the endoplasmic reticulum (ER) and the mitochondria establish a tight
interplay, which is structurally and functionally modulated through a proteinaceous tether …

Mitochondrial Ca2+ uptake has key roles in cell life and death. Physiological Ca2+ signaling
regulates aerobic metabolism, whereas pathological Ca2+ overload triggers cell death …

The endoplasmic reticulum (ER) as an intracellular Ca2+ store not only sets up cytosolic
Ca2+ signals, but, among other functions, also assembles and folds newly synthesized …

Abstract Intracellular calcium (Ca 2+) is a critical coordinator of various aspects of cellular
physiology. It is increasingly apparent that changes in cellular Ca 2+ dynamics contribute to …

Ischemic stroke is a severe cerebrovascular disease with high mortality and morbidity. In
recent years, reperfusion treatments based on thrombolytic and thrombectomy are major …

Significance: In all cells, the endoplasmic reticulum (ER) and mitochondria are physically
connected to form junctions termed mitochondria-associated membranes (MAMs). This …

Endoplasmic reticulum (ER) stress–induced apoptosis is involved in many diseases, but the
mechanisms linking ER stress to apoptosis are incompletely understood. Based on roles for …

Cellular organelles are not static but show dynamism—a property that is likely relevant for
their function. In addition, they interact with other organelles in a highly dynamic manner. In …