Calcium homeostasis is central to all cellular functions and has been studied for decades.
Calcium acts as a critical second messenger for both extracellular and intracellular signaling …

In Alzheimer disease (AD), the perturbation of the endoplasmic reticulum (ER) calcium
(Ca2+) homeostasis has been linked to presenilins, the catalytic core in γ-secretase …

Mitochondria-ER contact sites (MERCS) are known to underpin many important cellular
homoeostatic functions, including mitochondrial quality control, lipid metabolism, calcium …

Organelle localization is often crucial to properly modulate cellular functions and signalling
cascades. For example, the distribution of organelles in axons is crucial for their function and …

Mitochondria, as the powerhouse organelle of cells, are greatly involved in regulating cell
signaling pathways, including those related to the innate and acquired immune systems …

Membrane-bound organelles such as mitochondria, peroxisomes, or the endoplasmic
reticulum (ER) create distinct environments to promote specific cellular tasks such as ATP …

Alteration of mitochondria-associated membranes (MAMs) has been proposed to contribute
to the pathogenesis of Alzheimer's disease (AD). We studied herein the subcellular …

Inter-organellar communication often takes the form of Ca2+ signals. These Ca2+ signals
originate from the endoplasmic reticulum (ER) and regulate different cellular processes like …

In many physiological contexts, intracellular reduction–oxidation (redox) conditions and the
unfolded protein response (UPR) are important for the control of cell life and death …

Inside cells, the endoplasmic reticulum (ER) forms the largest Ca 2+ store. Ca 2+ is actively
pumped by the SERCA pumps in the ER, where intraluminal Ca 2+-binding proteins enable …