Inside cells, the endoplasmic reticulum (ER) forms the largest Ca 2+ store. Ca 2+ is actively
pumped by the SERCA pumps in the ER, where intraluminal Ca 2+-binding proteins enable …

The endoplasmic reticulum (ER) is a highly dynamic organelle of fundamental importance
present in all eukaryotic cells. The majority of synthesized structural and secreted proteins …

Unfolded protein response (UPR) is an adaptive response which is used for re-establishing
protein homeostasis, and it is triggered by endoplasmic reticulum (ER) stress. Specific ER …

The maintenance of cellular homeostasis involves the participation of multiple organelles.
These organelles are associated in space and time, and either cooperate or antagonize …

When cellular organelles communicate bad things can happen. Recent findings uncovered
that the junction between the endoplasmic reticulum (ER) and the mitochondria holds a …

The endoplasmic reticulum (ER) stress response constitutes a cellular process that can be
triggered by a great variety of conditions that cause imbalances in intracellular homeostasis …

The endoplasmic reticulum (ER) is involved in many cellular functions, including protein
folding and Ca2+ homeostasis. The ability of cells to respond to the ER stress is critical for …

Under physiological and pathological conditions, cells activate the unfolded protein
response (UPR) to deal with the accumulation of unfolded or misfolded proteins in the …

Ca2+ is an important second messenger participating in many cellular activities; when
physicochemical insults deregulate its delicate homeostasis, it acts as an intrinsic stressor …

Over the past years, knowledge and evidence about the existence of crosstalks between
cellular organelles and their potential effects on survival or cell death have been constantly …