BACKGROUND & AIMS: Mechanisms underlying synergistic liver injury caused by alcohol
and obesity are not clear. We have produced a mouse model of synergistic steatohepatitis …

The mechanisms underlying pathophysiological states such as metabolic syndrome and
obesity include endoplasmic reticulum (ER) stress and aberrant inflammatory responses. ER …

The endoplasmic reticulum has a central role in biosynthesis of a variety of proteins and
lipids. Mitochondria generate ATP, synthesize and process numerous metabolites, and are …

The tight cross talk between two essential organelles of the cell, the endoplasmic reticulum
(ER) and mitochondria, is spatially and functionally regulated by specific microdomains …

In order to maintain proper cellular functions, all living cells, from bacteria to mammalian
cells, must carry out a rigorous quality control process in which nascent and newly …

BACKGROUND: Cachexia is a wasting condition that manifests in several types of cancer,
and the main characteristic is the profound loss of muscle mass. METHODS: The Yoshida …

Steroid receptors existing outside the nucleus are increasingly being recognized in many
organs and cell types, impacting the biology of bone, the heart and blood vessels, and the …

The endoplasmic reticulum (ER) performs multiple functions in the cell: it is the major site of
protein and lipid synthesis as well as the most important intracellular Ca2+ reservoir …

Intrinsic and acquired chemoresistance are frequent causes of cancer eradication failure.
Thus, long-term cis-diaminedichloroplatine (II)(CDDP) or cisplatin treatment is known to …

Mechanosensory hair cells are vulnerable to environmental insult, resulting in hearing and
balance disorders. We demonstrate that directional compartmental flow of intracellular Ca2+ …