The liver fulfills central roles in metabolic control and detoxification and, as such, is
continuously exposed to a plethora of insults. Importantly, the liver has a unique ability to …

The endoplasmic reticulum (ER) is a dynamic organelle that is essential for multiple cellular
functions. During cellular stress conditions, including nutrient deprivation and dysregulation …

Mitochondria-associated endoplasmic reticulum membranes (MAMs) are dynamic coupling
structures between mitochondria and the endoplasmic reticulum (ER). As a new subcellular …

We previously reported that a cyclometalated iridium (Ir) complex-peptide hybrid (IPH) 4
functionalized with a cationic KKKGG peptide unit on the 2-phenylpyridine ligand induces …

Cardiovascular system cell biology is tightly regulated and mitochondria play a relevant role
in maintaining heart function. In recent decades, associations between such organelles and …

The outer mitochondrial membrane is a busy place. One essential activity for cellular
survival is the regulation of membrane integrity by the BCL‐2 family of proteins. Another …

Calcium signaling plays an important role in cell survival by influencing mitochondria-related
processes such as energy production and apoptosis. The endoplasmic reticulum (ER) is the …

Miner1 is a redox‐active 2Fe2S cluster protein. Mutations in Miner1 result in Wolfram
Syndrome, a metabolic disease associated with diabetes, blindness, deafness, and a …

Nitric oxide (NO) and other reactive nitrogen species target multiple sites in the mitochondria
to influence cellular bioenergetics and survival. Kinetic imaging studies revealed that NO …

Yessotoxin at nanomolar concentrations can induce programmed cell death in different
model systems. Paraptosis-like cell death induced by YTX in BC3H1 cells, which are …