The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), is an unprecedented global health crisis. However, therapeutic options for …

Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …

During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and
collaborative drug discovery efforts took place in academia and industry, culminating in …

Highlights•Structural biology plays a vital role in SARS-CoV-2 vaccine and treatment.•High-
resolution structures of SARS-CoV-2 proteins and complexes have been obtained.•In situ …

The emergence of SARS-CoV-2 infection has posed unprecedented threat to global public
health. The virus-encoded non-structural protein 14 (nsp14) is a bi-functional enzyme …

Abstract Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and is characterized by a delayed interferon (IFN) response …

Self-supervised pretraining on protein sequences has led to state-of-the art performance on
protein function and fitness prediction. However, sequence-only methods ignore the rich …

Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the causative agent of
coronavirus disease 2019 (COVID‐19), has caused millions of deaths in the past two years …

Background and aim A novel coronavirus, called the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has been found to cause COVID-19 in humans and some …

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
developed into an unprecedented global pandemic. Nucleoside analogs, such as …