Structural biology of SARS-CoV-2 and implications for therapeutic development
H Yang, Z Rao - Nature Reviews Microbiology, 2021 - nature.com
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), is an unprecedented global health crisis. However, therapeutic options for …
(SARS-CoV-2), is an unprecedented global health crisis. However, therapeutic options for …
Structural biology of SARS-CoV-2: open the door for novel therapies
W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …
Accelerating antiviral drug discovery: lessons from COVID-19
During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and
collaborative drug discovery efforts took place in academia and industry, culminating in …
collaborative drug discovery efforts took place in academia and industry, culminating in …
[HTML][HTML] A structural view of the SARS-CoV-2 virus and its assembly
NJ Hardenbrook, P Zhang - Current opinion in virology, 2022 - Elsevier
Highlights•Structural biology plays a vital role in SARS-CoV-2 vaccine and treatment.•High-
resolution structures of SARS-CoV-2 proteins and complexes have been obtained.•In situ …
resolution structures of SARS-CoV-2 proteins and complexes have been obtained.•In situ …
Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity
S Lin, H Chen, Z Chen, F Yang, F Ye… - Nucleic acids …, 2021 - academic.oup.com
The emergence of SARS-CoV-2 infection has posed unprecedented threat to global public
health. The virus-encoded non-structural protein 14 (nsp14) is a bi-functional enzyme …
health. The virus-encoded non-structural protein 14 (nsp14) is a bi-functional enzyme …
Mechanisms of antiviral immune evasion of SARS-CoV-2
DK Beyer, A Forero - Journal of molecular biology, 2022 - Elsevier
Abstract Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and is characterized by a delayed interferon (IFN) response …
coronavirus 2 (SARS-CoV-2) and is characterized by a delayed interferon (IFN) response …
Masked inverse folding with sequence transfer for protein representation learning
KK Yang, N Zanichelli, H Yeh - Protein Engineering, Design and …, 2023 - academic.oup.com
Self-supervised pretraining on protein sequences has led to state-of-the art performance on
protein function and fitness prediction. However, sequence-only methods ignore the rich …
protein function and fitness prediction. However, sequence-only methods ignore the rich …
Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the causative agent of
coronavirus disease 2019 (COVID‐19), has caused millions of deaths in the past two years …
coronavirus disease 2019 (COVID‐19), has caused millions of deaths in the past two years …
[HTML][HTML] In-silico evaluation of bioactive compounds from tea as potential SARS-CoV-2 nonstructural protein 16 inhibitors
R Singh, VK Bhardwaj, J Sharma, R Purohit… - Journal of traditional and …, 2022 - Elsevier
Background and aim A novel coronavirus, called the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has been found to cause COVID-19 in humans and some …
coronavirus 2 (SARS-CoV-2) has been found to cause COVID-19 in humans and some …
Structural basis of SARS-CoV-2 polymerase inhibition by favipiravir
Q Peng, R Peng, B Yuan, M Wang, J Zhao, L Fu, J Qi… - The Innovation, 2021 - cell.com
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
developed into an unprecedented global pandemic. Nucleoside analogs, such as …
developed into an unprecedented global pandemic. Nucleoside analogs, such as …