Background Many patients report symptomatic relief after undergoing arthroscopy of the
knee for osteoarthritis, but it is unclear how the procedure achieves this result. We …

Randomized trials are thought to provide optimal evidence if carried out correctly. Their
application to important questions is the best guide to clinical decision-making. However …

Background Our aim was to determine the evidence for thromboprophylaxis for prevention of
symptomatic venous thromboembolism (VTE) in adults with foot or ankle trauma treated with …

Background Using a larger, more comprehensive sample, and inclusion of the reverse
shoulder arthroplasty as a primary surgical approach for proximal humerus fracture, we …

Background: Literature guiding the management of early-onset scoliosis consists primarily of
studies with a low level of evidence. Evaluation of clinical equipoise (ie, when there is no …

An adequate sample size is crucial to a study's ability to correctly determine whether a
difference between study groups exists. Yet, determining the necessary sample size to …

Background The objective of the present study was to perform a systematic review and meta-
analysis of randomized controlled trials looking at the effect of distal clavicle resection in …

Summary Introduction Randomized controlled trials (RCTs) are considered the gold
standard for assessing treatment efficacy. However, pediatric surgical RCTs have been …

Background and purpose Hip fractures are among the top causes of global disability.
Conduction of high-quality studies such as randomized controlled trials to assess the …

Randomized controlled trials continue to be at the pinnacle of the evidence hierarchy. With
this unique vantage point, they inform medical practice, clinical guidelines, health policy …