Organotypic tissue slice culture is established from animal or patient tissues and cultivated
in an in vitro ecosystem. This technique has made countless contributions to anticancer drug …

The fields of regenerative medicine and tissue engineering offer significant promise to
address the urgent unmet need for therapeutic strategies in a number of debilitating …

The pathogenesis of glioblastoma (GBM) is characterized by highly invasive behavior
allowing dissemination and progression. A conclusive image of the invasive process is not …

Glioblastoma is an extremely lethal cancer characterized by great heterogeneity at different
molecular and cellular levels. As a result, treatment options have moved far from systemic …

Glioblastoma (GBM) invasion and migration are key biological behaviors leading to
refractoriness to current therapies and infiltration into the non‑tumor brain parenchyma. GBM …

Glioblastoma is a very aggressive tumor and represents the most common primary brain
malignancy. Key characteristics include its high resistance against conventional treatments …

Widespread tumor cell invasion is a fundamental property of diffuse gliomas and is
ultimately responsible for their poor prognosis. A greater understanding of basic …

The chick embryo has been an ideal model system for the study of vertebrate development,
particularly for experimental manipulations. Use of the chick embryo has been extended for …

Cancer is one of the most devastating diseases of our time, with 17 million new cancer
cases and 9.5 million cancer deaths in 2018 worldwide. The mortality associated with …

Brain tumours have significant impacts on patients' quality of life, and current treatments
have limited effectiveness. To improve understanding of tumour development and explore …