Parkinson's disease (PD) is a neurodegenerative disorder characterized by a preferential
loss of the dopaminergic neurons of the substantia nigrapars compacta. Although the …

Parkinson's disease (PD) is a common disabling neurodegenerative disorder the cardinal
clinical features of which include tremor, rigidity and slowness of movement (Fahn and …

This protocol describes our method of producing a reliable mouse model of Parkinson's
disease (PD) using the neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) …

Mechanisms responsible for 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced
dopamine (DA) neuronal death remain unknown and in mice it is even unclear whether …

The investigation of pathogenic and pathophysiological mechanisms of Parkinson's disease
relies on experimental models reproducing, in the animal, the pathological and behavioural …

Animal models are an important aid in experimental medical science because they enable
one to study the pathogenetic mechanisms and the therapeutic principles of treating the …

Astrocytes assume multiple roles in maintaining an optimally suited milieu for neuronal
function. Select astrocytic functions include the maintenance of redox potential, the …

1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) causes nigrostriatal dopaminergic
pathway damage similar to that observed in Parkinson disease (PD). To study the role of NO …

We investigated the hypothesis that neural stem cells (NSCs) possess an intrinsic capacity
to “rescue” dysfunctional neurons in the brains of aged mice. The study focused on a …

It is not yet established whether oxidative stress is a major cause of cell death or simply a
consequence of an unknown pathogenetic factor. Concerning chronic diseases, as …