Acute liver failure is a rare and devastating clinical condition. At present, emergency liver
transplantation is the only life-saving therapy in advanced cases, yet the feasibility of …

Comprehensive knowledge of host-pathogen interactions is central to understand the life
cycle of a pathogen and devise specific therapeutic strategies. Protein-protein interactions …

Progesterone is crucial for the maintenance of pregnancy. During pregnancy hepatitis E
virus (HEV) infection is associated with increased fulminant hepatic failure and mortality …

Hepatitis E virus (HEV) usually causes self-limiting acute hepatitis, but the disease can
become chronic in immunocompromised individuals. HEV infection in pregnant women is …

Acute liver failure (ALF) is a rare and severe disease, which, despite continuous advances in
medicine, is still characterized by high mortality (65-85%). Very often, a liver transplant is the …

Acute liver failure (ALF) is an infrequent, unpredictable, potentially fatal complication of
acute liver injury (ALI) consequent to varied etiologies. Etiologies of ALF as reported in the …

Hepatitis E virus (HEV) infection has been shown to activate NOD-like receptor family pyrin
domain–containing 3 (NLRP3) inflammasome in macrophages, a key mechanism of causing …

Hepatitis E virus (HEV) infection usually results in a self-limiting acute disease; however, in
infected pregnant women, it is associated with increased mortality and fulminant hepatic …

Hepatitis E virus (HEV) infection represents an emerging global health issue, whereas the
clinical outcomes vary dramatically among different populations. The host innate immune …

BACKGROUND Heterogeneous macrophages play an important role in multiple liver
diseases, including viral fulminant hepatitis (VFH). Fibrinogen-like protein 2 (FGL2) is …