Pathogenesis and treatment of Sjogren's syndrome: review and update

Q Zhan, J Zhang, Y Lin, W Chen, X Fan… - Frontiers in …, 2023 - frontiersin.org
Sjogren's syndrome (SS) is a chronic autoimmune disease accompanied by multiple
lesions. The main manifestations include dryness of the mouth and eyes, along with …

Systemic lupus erythematosus (SLE) therapy: the old and the new

F Basta, F Fasola, K Triantafyllias… - Rheumatology and …, 2020 - Springer
Despite recent improvements in the treatment of systemic lupus erythematosus (SLE),
disease activity, comorbidities and drug toxicity significantly contribute to the risk of …

The BAFF/APRIL system in SLE pathogenesis

FB Vincent, EF Morand, P Schneider… - Nature Reviews …, 2014 - nature.com
Systemic lupus erythematosus (SLE) is characterized by multisystem immune-mediated
injury in the setting of autoimmunity to nuclear antigens. The clinical heterogeneity of SLE …

The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity

FB Vincent, D Saulep-Easton, WA Figgett… - Cytokine & growth factor …, 2013 - Elsevier
The BAFF system plays a key role in the development of autoimmunity, especially in
systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly …

B cells in autoimmune diseases

CS Hampe - Scientifica, 2012 - Wiley Online Library
The role of B cells in autoimmune diseases involves different cellular functions, including the
well‐established secretion of autoantibodies, autoantigen presentation and ensuing …

Clinical associations of serum interleukin-17 in systemic lupus erythematosus

FB Vincent, M Northcott, A Hoi, F Mackay… - Arthritis research & …, 2013 - Springer
Abstract Introduction Serum interleukin (IL)-17 concentrations have been reported to be
increased in systemic lupus erythematosus (SLE), but associations with clinical …

Fecal microbiota transplantation modulates renal phenotype in the humanized mouse model of IgA nephropathy

G Lauriero, L Abbad, M Vacca, G Celano… - Frontiers in …, 2021 - frontiersin.org
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis.
Several observations suggest that gut microbiota could be implicated in IgAN …

B cell-activating factor (BAFF) from dendritic cells, monocytes and neutrophils is required for B cell maturation and autoantibody production in SLE-like autoimmune …

D Giordano, R Kuley, KE Draves, KB Elkon… - Frontiers in …, 2023 - frontiersin.org
Purpose and methods B cell-activating factor (BAFF) contributes to the pathogenesis of
autoimmune diseases including systemic lupus erythematosus (SLE). Although several anti …

The role of BAFF and APRIL in rheumatoid arthritis

AG Shabgah, Z Shariati‐Sarabi… - Journal of cellular …, 2019 - Wiley Online Library
Abstract Development and activation of B cells quickly became clear after identifying new
ligands and receptors in the tumor necrosis factor superfamily. B cell–activating factor …

Hyperactivation of the NLRP3 inflammasome in myeloid cells leads to severe organ damage in experimental lupus

A Lu, H Li, J Niu, S Wu, G Xue, X Yao… - The Journal of …, 2017 - journals.aai.org
Systemic lupus erythematosus (SLE) is an autoimmune syndrome associated with severe
organ damage resulting from the activation of immune cells. Recently, a role for caspase-1 …