Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and
asthma, affect millions of people all over the world. Cyclic adenosine monophosphate …

Evidence collected over the last ten years indicates that Epac and cAMP scaffold proteins
play a critical role in integrating and transducing multiple signaling pathways at the basis of …

Background and Purpose cAMP is a central second messenger that broadly regulates cell
function and can underpin pathophysiology. In chronic obstructive pulmonary disease, a …

Background. Last two decades, many association studies on genetic variants and chronic
obstructive pulmonary disease (COPD) risk have been published. But results from different …

Background: There is an acute need to uncover biomarkers that reflect the molecular
pathologies, underpinning prostate cancer progression and poor patient outcome. We have …

Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative
for disease progression and development of distant metastases - PMC Back to Top Skip to …

Genome-wide association studies aim to correlate genotype with phenotype. Many common
diseases including Type II diabetes, Alzheimer's, Parkinson's and Chronic Obstructive …

Background The clinical metrics used to date to assess the progression risk of newly
diagnosed prostate cancer patients only partly represent the true biological aggressiveness …

Background Chronic obstructive pulmonary disease (COPD) is characterized by incomplete
reversible airflow limitation and chronic inflammatory response lesions. This study mainly …

慢性阻塞性肺疾病(COPD) 是一种常见的慢性非传染性疾病, 以不完全可逆的气流受限呈进行性
发展为特征. COPD 患病率和死亡率均较高, 造成的疾病负担严重. COPD 存在个体易感性 …