Assessing the ecological risks of per‐and polyfluoroalkyl substances: Current state‐of‐the science and a proposed path forward
Per‐and poly‐fluoroalkyl substances (PFAS) encompass a large, heterogenous group of
chemicals of potential concern to human health and the environment. Based on information …
chemicals of potential concern to human health and the environment. Based on information …
In vitro to in vivo extrapolation for high throughput prioritization and decision making
SM Bell, X Chang, JF Wambaugh, DG Allen, M Bartels… - Toxicology in vitro, 2018 - Elsevier
In vitro chemical safety testing methods offer the potential for efficient and economical tools
to provide relevant assessments of human health risk. To realize this potential, methods are …
to provide relevant assessments of human health risk. To realize this potential, methods are …
Guidance for the identification of endocrine disruptors in the context of Regulations (EU) No 528/2012 and (EC) No 1107/2009
… Chemical Agency (ECHA) and European Food … - EFSA …, 2018 - Wiley Online Library
This Guidance describes how to perform hazard identification for endocrine‐disrupting
properties by following the scientific criteria which are outlined in Commission Delegated …
properties by following the scientific criteria which are outlined in Commission Delegated …
The role of omics in the application of adverse outcome pathways for chemical risk assessment
EK Brockmeier, G Hodges, TH Hutchinson… - Toxicological …, 2017 - academic.oup.com
In conjunction with the second International Environmental Omics Symposium (iEOS)
conference, held at the University of Liverpool (United Kingdom) in September 2014, a …
conference, held at the University of Liverpool (United Kingdom) in September 2014, a …
Verification of in vivo estrogenic activity for four per-and polyfluoroalkyl substances (PFAS) identified as estrogen receptor agonists via new approach methodologies
DL Villeneuve, BR Blackwell, JE Cavallin… - … science & technology, 2023 - ACS Publications
Given concerns about potential toxicological hazards of the thousands of data-poor per-and
polyfluorinated alkyl substances (PFAS) currently in commerce and detected in the …
polyfluorinated alkyl substances (PFAS) currently in commerce and detected in the …
Toward sustainable environmental quality: Priority research questions for Europe
Abstract The United Nations' Sustainable Development Goals have been established to end
poverty, protect the planet, and ensure prosperity for all. Delivery of the Sustainable …
poverty, protect the planet, and ensure prosperity for all. Delivery of the Sustainable …
Application of adverse outcome pathways to US EPA's endocrine disruptor screening program
P Browne, PD Noyes, WM Casey… - Environmental health …, 2017 - ehp.niehs.nih.gov
Background: The US EPA's Endocrine Disruptor Screening Program (EDSP) screens and
tests environmental chemicals for potential effects in estrogen, androgen, and thyroid …
tests environmental chemicals for potential effects in estrogen, androgen, and thyroid …
[HTML][HTML] Prioritizing chemicals of ecological concern in Great Lakes tributaries using high-throughput screening data and adverse outcome pathways
SR Corsi, LA De Cicco, DL Villeneuve… - Science of the Total …, 2019 - Elsevier
Chemical monitoring data were collected in surface waters from 57 Great Lakes tributaries
from 2010 to 13 to identify chemicals of potential biological relevance and sites at which …
from 2010 to 13 to identify chemicals of potential biological relevance and sites at which …
Simulated digestion of polystyrene foam enhances desorption of diethylhexyl phthalate (DEHP) and In vitro estrogenic activity in a size-dependent manner
Marine polychaetes and fish are known to ingest polystyrene microparticles in the
environment. Laboratory microplastic feeding experiments have demonstrated that plastic …
environment. Laboratory microplastic feeding experiments have demonstrated that plastic …
Evidence for cross species extrapolation of mammalian-based high-throughput screening assay results
CA LaLone, DL Villeneuve, JA Doering… - … science & technology, 2018 - ACS Publications
High-throughput screening (HTS) and computational technologies have emerged as
important tools for chemical hazard identification. The US Environmental Protection Agency …
important tools for chemical hazard identification. The US Environmental Protection Agency …