Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease

A Köfalvi, C Lemos, AM Martín-Moreno, BS Pinheiro… - …, 2016 - Elsevier
Abstract Cannabinoid CB 2 receptors (CB 2 Rs) are emerging as important therapeutic
targets in brain disorders that typically involve neurometabolic alterations. We here …

CB1 receptor activation inhibits neuronal and astrocytic intermediary metabolism in the rat hippocampus

JMN Duarte, SG Ferreira, RA Carvalho… - Neurochemistry …, 2012 - Elsevier
Cannabinoid CB1 receptor (CB1R) activation decreases synaptic GABAergic and
glutamatergic transmission and it also controls peripheral metabolism. Here we aimed at …

Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin

BS Pinheiro, C Lemos, FN Kaufmann, JM Marques… - Brain research …, 2016 - Elsevier
Here we asked if insulin activation of the nucleus accumbens in vitro is reflected by an
increase in 3 H-deoxyglucose ([3 H] DG) uptake, thus subserving a new model to study …

Impaired hippocampal glucoregulation in the cannabinoid CB1 receptor knockout mice as revealed by an optimized in vitro experimental approach

C Lemos, Â Valério-Fernandes, GC Ghisleni… - Journal of neuroscience …, 2012 - Elsevier
Several techniques exist to study the rate of glucose uptake and metabolism in the brain but
most of them are not sufficiently robust to permit extensive pharmacological analysis. Here …

Chronic insulinopenia/hyperglycemia decreases cannabinoid CB1 receptor density and impairs glucose uptake in the mouse forebrain

LIF Moura, C Lemos, C Ledent, E Carvalho… - Brain research …, 2019 - Elsevier
Both endocannabinoids and insulin regulate peripheral and cerebral glucose homeostasis
via convergent signaling pathways that are impacted by diabetes. Here we asked how …

Metabolic modifications associated with memory deficits

ACFL Rial - 2016 - estudogeral.uc.pt
This work started from the known premise that, in the brain, glucose availability regulates
memory and cognition in both healthy humans and dementia patients. Furthermore, cerebral …

Metabolic modifications associated with memory deficits

ACF de Lemos - 2016 - search.proquest.com
This work started from the known premise that, in the brain, glucose availability regulates
memory and cognition in both healthy humans and dementia patients. Furthermore, cerebral …

The Multifaceted Role of the Endocannabinoid System in the Regulation of Cerebral Glucose Uptake

AB da Silva Pinheiro - 2013 - search.proquest.com
Background and aims: The endocannabinoid system affects energy balance and glucose
metabolism through the central control of feeding behaviour. The reward area, nucleus …

Insulin Signalling Depends on the Endocannabinoid System in the Brain

CS da Silva Santos - 2013 - search.proquest.com
A insulina eo sistema endocanabinóide (eCB) exercem funções muito importantes no
organismo, tanto na periferia como no cérebro. Algumas destas funções são …

Insulin signalling depends on the endocannabinoid system in the brain

CSS Santos - 2013 - baes.uc.pt
Insulin and the endocannabinoid (eCB) system have important and common functions in
both peripheral and brain metabolism. This is due to the overlapping of their intracellular …