Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease
Abstract Cannabinoid CB 2 receptors (CB 2 Rs) are emerging as important therapeutic
targets in brain disorders that typically involve neurometabolic alterations. We here …
targets in brain disorders that typically involve neurometabolic alterations. We here …
CB1 receptor activation inhibits neuronal and astrocytic intermediary metabolism in the rat hippocampus
Cannabinoid CB1 receptor (CB1R) activation decreases synaptic GABAergic and
glutamatergic transmission and it also controls peripheral metabolism. Here we aimed at …
glutamatergic transmission and it also controls peripheral metabolism. Here we aimed at …
Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin
BS Pinheiro, C Lemos, FN Kaufmann, JM Marques… - Brain research …, 2016 - Elsevier
Here we asked if insulin activation of the nucleus accumbens in vitro is reflected by an
increase in 3 H-deoxyglucose ([3 H] DG) uptake, thus subserving a new model to study …
increase in 3 H-deoxyglucose ([3 H] DG) uptake, thus subserving a new model to study …
Impaired hippocampal glucoregulation in the cannabinoid CB1 receptor knockout mice as revealed by an optimized in vitro experimental approach
C Lemos, Â Valério-Fernandes, GC Ghisleni… - Journal of neuroscience …, 2012 - Elsevier
Several techniques exist to study the rate of glucose uptake and metabolism in the brain but
most of them are not sufficiently robust to permit extensive pharmacological analysis. Here …
most of them are not sufficiently robust to permit extensive pharmacological analysis. Here …
Chronic insulinopenia/hyperglycemia decreases cannabinoid CB1 receptor density and impairs glucose uptake in the mouse forebrain
Both endocannabinoids and insulin regulate peripheral and cerebral glucose homeostasis
via convergent signaling pathways that are impacted by diabetes. Here we asked how …
via convergent signaling pathways that are impacted by diabetes. Here we asked how …
Metabolic modifications associated with memory deficits
ACFL Rial - 2016 - estudogeral.uc.pt
This work started from the known premise that, in the brain, glucose availability regulates
memory and cognition in both healthy humans and dementia patients. Furthermore, cerebral …
memory and cognition in both healthy humans and dementia patients. Furthermore, cerebral …
Metabolic modifications associated with memory deficits
ACF de Lemos - 2016 - search.proquest.com
This work started from the known premise that, in the brain, glucose availability regulates
memory and cognition in both healthy humans and dementia patients. Furthermore, cerebral …
memory and cognition in both healthy humans and dementia patients. Furthermore, cerebral …
The Multifaceted Role of the Endocannabinoid System in the Regulation of Cerebral Glucose Uptake
AB da Silva Pinheiro - 2013 - search.proquest.com
Background and aims: The endocannabinoid system affects energy balance and glucose
metabolism through the central control of feeding behaviour. The reward area, nucleus …
metabolism through the central control of feeding behaviour. The reward area, nucleus …
Insulin Signalling Depends on the Endocannabinoid System in the Brain
CS da Silva Santos - 2013 - search.proquest.com
A insulina eo sistema endocanabinóide (eCB) exercem funções muito importantes no
organismo, tanto na periferia como no cérebro. Algumas destas funções são …
organismo, tanto na periferia como no cérebro. Algumas destas funções são …
Insulin signalling depends on the endocannabinoid system in the brain
CSS Santos - 2013 - baes.uc.pt
Insulin and the endocannabinoid (eCB) system have important and common functions in
both peripheral and brain metabolism. This is due to the overlapping of their intracellular …
both peripheral and brain metabolism. This is due to the overlapping of their intracellular …