Genetics meets proteomics: perspectives for large population-based studies
Proteomic analysis of cells, tissues and body fluids has generated valuable insights into the
complex processes influencing human biology. Proteins represent intermediate phenotypes …
complex processes influencing human biology. Proteins represent intermediate phenotypes …
Intestinal microbiome and fitness in kidney disease
B Meijers, P Evenepoel, HJ Anders - Nature reviews nephrology, 2019 - nature.com
Environmental changes can induce diversity shifts within ecosystems that affect interactions
between species. Similarly, the development of kidney disease induces shifts within the …
between species. Similarly, the development of kidney disease induces shifts within the …
Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome
The levels of the thousands of metabolites in the human plasma metabolome are strongly
influenced by an individual's genetics and the composition of their diet and gut microbiome …
influenced by an individual's genetics and the composition of their diet and gut microbiome …
Large-scale association analyses identify host factors influencing human gut microbiome composition
A Kurilshikov, C Medina-Gomez, R Bacigalupe… - Nature …, 2021 - nature.com
To study the effect of host genetics on gut microbiome composition, the MiBioGen
consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data …
consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data …
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals
L Folkersen, S Gustafsson, Q Wang, DH Hansen… - Nature …, 2020 - nature.com
Circulating proteins are vital in human health and disease and are frequently used as
biomarkers for clinical decision-making or as targets for pharmacological intervention. Here …
biomarkers for clinical decision-making or as targets for pharmacological intervention. Here …
jMorp updates in 2020: large enhancement of multi-omics data resources on the general Japanese population
S Tadaka, E Hishinuma, S Komaki… - Nucleic acids …, 2021 - academic.oup.com
Abstract In the Tohoku Medical Megabank project, genome and omics analyses of
participants in two cohort studies were performed. A part of the data is available at the …
participants in two cohort studies were performed. A part of the data is available at the …
[HTML][HTML] Host genetic regulation of human gut microbial structural variation
Although the impact of host genetics on gut microbial diversity and the abundance of specific
taxa is well established,,,,–, little is known about how host genetics regulates the genetic …
taxa is well established,,,,–, little is known about how host genetics regulates the genetic …
Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity
L Chen, V Collij, M Jaeger… - Nature …, 2020 - nature.com
The gut microbiome is an ecosystem that involves complex interactions. Currently, our
knowledge about the role of the gut microbiome in health and disease relies mainly on …
knowledge about the role of the gut microbiome in health and disease relies mainly on …
Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut
The molecular bases of how host genetic variation impacts the gut microbiome remain
largely unknown. Here we used a genetically diverse mouse population and applied …
largely unknown. Here we used a genetically diverse mouse population and applied …
Gut microbial associations to plasma metabolites linked to cardiovascular phenotypes and risk: a cross-sectional study
A Kurilshikov, ICL van den Munckhof, L Chen… - Circulation …, 2019 - Am Heart Assoc
Rationale: Altered gut microbial composition has been linked to cardiovascular diseases
(CVDs), but its functional links to host metabolism and immunity in relation to CVD …
(CVDs), but its functional links to host metabolism and immunity in relation to CVD …