Substance P (SP) is an undecapeptide present in the CNS and the peripheral nervous
system. SP released from the peripheral nerves exerts its biological and immunological …

Unnatural α-amino acids form a family of essential molecules used for, among other
applications, the synthesis of modified peptides, to improve resistance to proteolytic enzyme …

Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …

This paper advances a psychophysiological systems view of pain in which physical injury, or
wounding, generates a complex stress response that extends beyond the nervous system …

The neurokinin 1 receptor (NK‐1R) is the main receptor for the tachykinin family of peptides.
Substance P (SP) is the major mammalian ligand and the one with the highest affinity. SP is …

The brain, particularly the hypothalamus, integrates input from factors that stimulate
(orexigenic) and inhibit (anorexigenic) food intake. In fish, the identification of appetite …

Increasing evidence accumulated during the past two decades has demonstrated that the
then-novel kisspeptin, which was discovered in 2001, the known neuropeptides neurokinin …

The skin, including the hypodermis, is the largest body organ and is in constant contact with
the environment. Neurogenic inflammation is the result of the activity of nerve endings and …

Pubertal onset is thought to be timed by an increase in pulsatile gonadotropin-releasing
hormone (GnRH)/gonadotropin secretion in mammals. The underlying mechanism of …

A vast number of marketed drugs act on G protein‐coupled receptors (GPCRs), the most
successful category of drug targets to date. These drugs usually possess high target affinity …