The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

Programmed cell death 1 receptor (PD-1) and its ligands constitute an inhibitory pathway to
mediate the mechanism of immune tolerance and provide immune homeostasis …

We report the updated classification of inborn errors of immunity, compiled by the
International Union of Immunological Societies Expert Committee. This report documents the …

Phenotypic and transcriptional profiling of regulatory T (Treg) cells at homeostasis reveals
that T cell receptor activation promotes Treg cells with an effector phenotype (eTreg) …

The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for
antitumor responses and effective immune checkpoint blockade (ICB) therapy. Here, we …

With immune checkpoint inhibitors (ICIs) becoming the mainstay of treatment for many
cancers, managing their immune-related adverse events (irAEs) has become an important …

The molecular basis of interindividual clinical variability upon infection with Staphylococcus
aureus is unclear. We describe patients with haploinsufficiency for the linear deubiquitinase …

Immune checkpoint inhibitors (ICIs) have revolutionised cancer treatment. However, immune-
related adverse events (irAEs) are a common side effect which can mimic infection …

The immune system plays critical roles in both autoimmunity and cancer, diseases at
opposite ends of the immune spectrum. Autoimmunity arises from loss of T cell tolerance …

Human genetic variants that introduce an AG into the intronic region between the
branchpoint (BP) and the canonical splice acceptor site (ACC) of protein-coding genes can …