Many oxidation–reduction (redox) enzymes, particularly oxygenases, have roles in reactions
that make and break C–C bonds. The list includes cytochrome P450 and other heme-based …

The following acetylenic substrates have been shown to mediate NADPH-dependent loss of
cytochrome P-450 on incubation with hepatic microsomes from phenobarbital-pretreated …

The oxidation of carbon–carbon triple bonds by cytochrome P450 produces ketene
metabolites that are hydrolyzed to acetic acid derivatives or are trapped by nucleophiles. In …

Dissolved organic matter (DOM) mediates the microbial transformation of micropollutants,
including norgestrel (NGT) in natural waters. However, little is known of the effect of complex …

Norethisterone, levonorgestrel, cyproterone acetate and gestodene have been used for a
long time in oral contraception and other indications, or are in the process of development …

The oral contraceptive 17-α-ethynylestradiol (17EE) is a mechanism-based inactivator of
cytochrome P450s (P450s) 2B1 and 2B6. Inactivation of P450s 2B1 and 2B6 in the …

Abstract Oxidation of 1-[13 C] biphenylacetylene by either meta-chloroperbenzoic acid or by
liver microsomes from phenobarbital-pretreated rats yields (after esterification) methyl 2 …

Metabolism of the 17 alpha-ethynyl group of the synthetic estrogen, 17 alpha-
ethynylestradiol, by hepatic microsomes from female rhesus monkeys was studied …

17 alpha-Ethynylestradiol (EE2)[20, 21-14C] and [9, 11-3H] were administered by
intragastric intubation to three adult female rhesus monkeys. Quantification of the tritium …

THE ROLE OF PHARMACOKINETICS IN PRECLINICAL SAFETY STUDIES OF SYNTHETIC SEX
STEROIDS Michael Humpel, B. Dusterberg, S. Beier, J. Page 1 THE ROLE OF …