The rapid development of microbial resistance to conventional antibiotics has accelerated
efforts to find anti-infectives with a novel mode-of-action, which are less prone to bacterial …

Purpose To provide a precise summary and collate the hitherto available clinical evidence
on the effect of vitamin D supplementation on clinical outcomes in COVID-19 patients …

The 2019 novel respiratory virus (SARS-CoV-2) causes COVID-19 with rapid global
socioeconomic disruptions and disease burden to healthcare. The COVID-19 and previous …

Abstract The coronavirus disease 2019 (COVID-19) pandemic was declared a public health
emergency of international concern by the World Health Organization. COVID-19 has high …

The COVID-19 pandemic has evidenced the urgent need for the discovery of broad-
spectrum antiviral therapies that could be deployed in the case of future emergence of novel …

The golden era of antibiotics, heralded by the discovery of penicillin, has long been
challenged by the emergence of antimicrobial resistance (AMR). Host defense peptides …

The development of durable new antiviral therapies is challenging, as viruses can evolve
rapidly to establish resistance and attenuate therapeutic efficacy. New compounds that …

Keratinocytes, the main cells of the epidermis, are the first site of replication as well as the
first line of defense against many viruses such as arboviruses, enteroviruses, herpes …

As the first line of defense against risk factors, the nasal epithelial barrier maintains
homeostasis in nasal mucosa. The composition of the epithelial barrier contains physical …

In the last few decades, antimicrobial peptides (AMPs) have been explored as an alternative
to classical antibiotics, which in turn motivated the development of machine learning models …